医学影像处理与分析

硕士研究生

081104-模式识别与智能系统
081203-计算机应用技术
083100-生物医学工程

医学影像处理与分析
生物特征识别与系统

2005-09--2009-09   香港大学（The University of Hong Kong）   博士
2002-09--2005-07   大连医科大学   硕士
1997-09--2002-07   大连医科大学   学士

博士研究生

博士

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2017-11~现在, 中国科学院自动化研究所, 研究员
2012-11~2017-10,中国科学院自动化研究所, 副研究员
2010-04~2012-09,The Univ of Texas Southwestern Medical Center, 博士后
2009-10~2010-03,The Univ of Texas MD Anderson Cancer Center, 博士后

   

（1） 世界分子影像大会研究学者奖, 其他, 2017
（2） 美国肿瘤年会新视野大会旅行资助奖, 其他, 2016
（3） 世界分子影像大会研究学者奖, 其他, 2015
（4） 亚洲分子影像大会旅行资助, 其他, 2013

（ 1 ） 基于稀疏度自适应组正交匹配追踪的激发荧光断层重建方法, 发明, 2019, 第 2 作者, 专利号: 201910548816.0
（ 2 ） 基于自适应参数搜索的弹性网络激发荧光断层重建系统, 发明, 2020, 第 2 作者, 专利号: 202010301564.4
（ 3 ） 一种光声和荧光循环互提升成像方法, 发明, 2015, 第 4 作者, 专利号: ZL2013103644218

   

（ 1 ） 针对肿瘤相关巨噬细胞在乳腺肿瘤发展中分布和作用的分子影像学研究, 主持, 国家级, 2015-05--2018-12
（ 2 ） 小动物光学和光声断层多模融合分子影像设备, 主持, 部委级, 2014-01--2015-12
（ 3 ） 脑胶质瘤精准诊疗技术的关键科学问题研究, 参与, 国家级, 2015-01--2019-12
（ 4 ） 多模态医学影像技术在视网膜疾病的发生发展及视网膜组织工程修复中的应用, 参与, 国家级, 2014-01--2018-12
（ 5 ） 针对早期乳腺肿瘤和微小转移的新型磁纳米粒子成像研究, 主持, 国家级, 2019-01--2022-12
（ 6 ） 中国科学院科技创新”交叉与合作团队”, 参与, 部委级, 2014-01--2014-12
（ 7 ） 中国科学院外籍青年科学家计划, 主持, 国家级, 2014-01--2015-12
（ 8 ） 北京市科技新星计划交叉学科合作课题“基于肿瘤分子影像技术中药调控乳腺癌作用评价体系关键方法研究”, 参与, 省级, 2017-01--2018-12
（ 9 ） 北京市科委“生命科学领域前沿技术培育”专项 “基于DNA纳米结构的多模态分子影像探针”, 参与, 省级, 2016-01--2018-12

（1）MPI/MRI-guided Magnetic Hyperthermia Therapy on 4T1 breast tumor mouse mode   2019-12-10
（2）Optimization of Magnetic Theranostic Agent for in vivo MPI/MRI-guided Magnetic Hyperthermia Therapy on 4T1 tumor mouse model   2019-09-04
（3）Comparison of anti-hepatocellular carcinoma efficacy between regorafenib and sorafenib    2019-03-29
（4）Endoscopic molecular imaging of early gastric cancer using fluorescently labeled human H-ferritin   2018-09-12
（5）A novel HDAC-targeted probe for triple-negative breast tumor imaging   2018-04-14
（6）A DNA Origami assembled with QD655 and gold nanorod working as a novel nanoprobe for fluorescence and optoacoustic dual modality imaging in 4T1 mammary tumor model   2017-09-13
（7）Improved resection and prolonged overall survival with PD-1-IRDye800CW fluorescent probe-guided surgery and PD-1 adjuvant immunotherapy   2017-04-01
（8）Evaluation of the anti-neoplastic effect of sorafenib on liver cancer through bioluminescence tomography   2017-02-11
（9）PD-1-IRDye800CW as a novel probe for fluorescence molecular imaging and image guided intraoperative surgery in breast tumor mouse model   2016-12-05
（10）Infra Red Dye labled programmed death 1 (PD-1) as a novel probe for fluorescence molecular imaging and image guided intraoperative surgery in 4T1 breast tumors   2016-09-07
（11）AS1411 aptamer guided QD655 labeled DNA Origami working as a novel nanoprobe for fluorescence molecular imaging in breast tumor mouse model    Du Yang   2015-09-03
（12）The gold nanorods decorated with DNA Origami structure working as a novel photoacoustic imaging probe in 4T1 breast tumor model   Yang Du, Nicolas Beziere, Qian Zhang, Ntziachristos Vasilis   2014-09-17
（13）GX1-conjugated Endostar: a new drug delivery system for anti-colorectal cancer in vivo   Qian Zhang, Yaqian Li, Xiaolong Liang, Xin Yang,    2013-09-20
（14）Application of Molecular Imaging Technology in Tumor Study   Du Yang   2013-05-30

已指导学生

梁倩  硕士研究生  085211-计算机技术  

现指导学生

孔令鑫  硕士研究生  081104-模式识别与智能系统  

边畅  硕士研究生  081104-模式识别与智能系统  

王宇  硕士研究生  081104-模式识别与智能系统  

（1） Combination immunotherapy with cytotoxic T lymphocyte-associated antigen-4 and programmed death protein-1 inhibitors prevents postoperative breast tumor recurrence and metastasis, Mol Cancer Ther, 2020, 通讯作者
（2） Reconstruction for Fluorescence Molecular Tomography via Adaptive Group Orthogonal Matching Pursuit, IEEE Trans Biomed Eng, 2020, 通讯作者
（3） Identification of HDAC9 as a viable therapeutic target for the treatment of gastric cancer, Exp Mol Med, 2019, 通讯作者
（4） Synergistic triple-combination therapy with hyaluronic acid-shelled PPy/CPT nanoparticles results in tumor regression and prevents tumor recurrence and metastasis in 4T1 breast cancer, Biomaterials, 2019, 第 2 作者
（5） Antitumorigenic and antiangiogenic efficacy of apatinib in liver cancer evaluated by multimodality molecular imaging, Exp Mol Med, 2019, 通讯作者
（6） Ferrimagnetic Vortex Nanoring-Mediated Mild Magnetic Hyperthermia Imparts Potent Immunological Effect for Treating Cancer Metastasis, ACS Nano, 2019, 通讯作者
（7） Noninvasive Imaging in Cancer Immunotherapy: The Way to Precision Medicine, Cancer Lett, 2019, 第 1 作者
（8） Development of Novel Selective Histone Deacetylase 6 Inhibitor for in vivo Breast Tumor Therapy and Targeted Imaging, Journal of Materials Chemistry B, 2019, 第 2 作者
（9） Preclinical comparison of regorafenib and sorafenib efficacy for hepatocellular carcinoma using multimodality molecular imaging, Cancer Letters, 2019, 第 2 作者
（10） Optimization of Magnetic Theranostic Agent for in vivo MPI/MRI-guided Magnetic Hyperthermia Therapy, Nano Letters, 2019, 第 1 作者
（11） Liposomal Nanohybrid Cerasomes Targeted to PD-L1 Enable Dual-Modality Imaging and Improve Antitumor Treatments, Cancer Letters, 2018, 第 1 作者
（12） Glioma-targeted imaging and therapy by Y1 receptors ligands stabilized nanomicelles across the blood brain barrier, Nanoscale, 2018, 第 2 作者
（13） The fluorescence molecular imaging and tomography of matrix metalloproteinase-activatable near infrared fluorescence probe and image-guided orthotopic glioma resection, Mol Imaging Biol, 2018, 第 2 作者
（14） Radiomics analysis allows for precise prediction of epilepsy in patients with low-grade gliomas, NeuroImage:Clinical, 2018, 第 4 作者
（15） Prediction of the anti-glioma therapeutic effects of temozolomide through the in vivo molecular imaging of the MMP expression, Biomedical Optics Express, 2018, 第 2 作者
（16） PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model, BMC Cancer, 2018, 第 2 作者
（17） EGFR-targeted liposomal nanohybrid cerasomes: theranostic function and immune checkpoint inhibition in a mouse model of colorectal cancer, Nanoscale, 2018, 第 2 作者
（18） Development of a Novel Ferrocenyl Histone Deacetylase Inhibitor for Triple-Negative Breast Cancer Therapy, Organometallics, 2018, 第 2 作者
（19） A novel estrogen receptor α-targeted near-infrared fluorescent probe for in vivo detection of breast tumor, Molecular Pharmaceutics, 2018, 第 2 作者
（20） Advances in Molecular Imaging of Immunotherapeutic Targets in Breast Cancer: Current and Future Prospect, European Radiology, 2018, 第 1 作者
（21） Endoscopic molecular imaging of early gastric cancer using fluorescently labeled human H-ferritin, Nanomedicine-Nanotechnology Biology and Medicine, 2018, 第 1 作者
（22） Sparse reconstruction of fluorescence molecular tomography using variable splitting and alternating direction scheme, Mol Imaging Biol, 2017, 第 2 作者
（23） Improved resection and prolonged overall survival with PD-1-IRDye800CW fluorescence probe-guided surgery and PD-1 adjuvant immunotherapy in 4T1 mouse model, International Journal of Nanomedicine, 2017, 第 1 作者
（24） Nuclear and fluorescent labeled PD-1-Liposome-DOX-64Cu/IRDye800CW allows improved breast tumor targeted imaging and therapy, Mol Pharmacuetics, 2017, 第 1 作者
（25） Evaluation of the anti-neoplastic effect of sorafenib on liver cancer through bioluminescence tomography, SPIE Medical Imaging, 2017, 第 3 作者
（26） Theranostic Gold Nanorod‒DNA Origami Hybrids for Enhanced in vivo Optoacoustic Imaging and Photothermal Therapy, Advanced Materials, 2016, 第 1 作者
（27） Precise diagnosis in different scenarios using photoacoustic and fluorescence imaging with dual-modality nanoparticles, Nanoscale, 2016, 第 2 作者
（28） Infra Red Dye and Endostar Loaded Poly Lactic Acid Nano Particles as a Novel Theranostic Nanomedicine for Breast Cancer, Journal of Biomedical Nanotechnology, 2016, 第 2 作者
（29） Core-Shell Gold Nanorod@Metal-Organic Framework Nanoprobes for Multimodality Diagnosis of Glioma, Advanced Materials, 2016, 第 3 作者
（30） Activation of Mesenchymal Stem Cells by Macrophages Promotes Tumor Progression through Immune Suppressive Effects, Oncotarget, 2016, 第 4 作者
（31） Self-assembled Gold DNA Nanoparticles for Cancer Theranostics, Small, 2015, 通讯作者
（32） Increased precision of orthotopic and metastatic breast cancer surgery guided by matrix metalloproteinase-activatable near-infrared fluorescence probes, Scentific Reports, 2015, 通讯作者
（33） GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar for improved in vivo anticolorectal cancer treatment, International Journal of Nanomedicine, 2015, 第 1 作者
（34） Zoledronic Acid Prevents the Tumor-promoting effects of Mesenchymal Stem, Oncotarget, 2015, 第 1 作者
（35） Monitoring Tumor Targeting and Treatment Effects of IRDye 800CW and GX1-conjugated Poly Lactic Acid Nanoparticles Encapsulating Endostar on Glioma by Optical Molecular Imaging, Molecular imaging, 2015, 第 1 作者
（36） Maternal Adiponectin Controls Milk Composition to Prevent Neonatal Inflammation, Endocrinology, 2015, 第 2 作者
（37） DNA origami as an in vivo drug delivery vehicle for cancer therapy, ACS Nano, 2014, 通讯作者
（38） The PEG Coated TiO2 Nanocarriers with Enhanced Chemotherapeutic Effects of Doxorubicin in vivo: Evidence from Orthotopic Breast Tumor Bearing Mouse Model, Journal of Materials Chemistry B, 2014, 第 1 作者
（39） Comprehensive evaluation of the anti-angiogenic and anti-neoplastic effects of Endostar on liver cancer through optical molecular imaging, PLoS One, 2014, 第 1 作者
（40） Intraoperative imaging-guided cancer surgery: from current fluorescence molecular imaging methods to future multi-modality imaging technology, Theranostics, 2014, 第 2 作者
（41） Maternal Adiponectin Controls Milk Composition to Prevent Neonatal Inflammation, Endocrinology, 2014, 第 2 作者
（42） Reconstruction of fluorescence molecular tomography via a nonmonotone spectral projected gradient pursuit method, Journal of Biomedical Optics, 2014, 第 2 作者
（43） (18)F-fluorodeoxyglucose uptake and tumor hypoxia: revisit (18)f-fluorodeoxyglucose in oncology application, Translational Oncology, 2014, 第 2 作者
（44） Mitochondrial complex I activity suppresses inflammation and enhances bone resorption by shifting macrophage-osteoclast polarization, Cell Metabolism, 2014, 第 4 作者
（45） Macrophage VLDL receptor promotes PAFAH secretion in mothers milk and suppresses systemic inflammation in nursing neonates, Nature Communications, 2012, 第 1 作者
（46） Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity, Genes and development, 2012, 第 1 作者