1、         天然免疫新亚群发现与抗感染/抗肿瘤机制

2、         非编码RNA与免疫调控

3、         肿瘤干细胞与肿瘤免疫

   

071010-生物化学与分子生物学
100102-免疫学

肿瘤免疫
肿瘤干细胞
免疫细胞发育

   

（1） 2009年度北京市自然科学奖，三等奖，省级，2010

（1） 人膀胱癌肿瘤标志物及其抗体和应用，发明，2010，第2作者，专利号：201010251384.6

   

[1] Guo, Hui, Zhang, Jiahang, Jiang, Zhimin, Zhu, Xiaoxiao, Yang, Jing, Mu, Rui, Du, Ying, Tian, Yong, Zhu, Pingping, Fan, Zusen. Noncoding RNA circBtnl1 suppresses self-renewal of intestinal stem cells via disruption of Atf4 mRNA stability. EMBO JOURNAL. 2023, 42(6): [2] Shao, Fei, Liu, Zhen, Wei, Qinglin, Yu, Dou, Zhao, Min, Zhang, Xusheng, Gao, Xintong, Fan, Zusen, Wang, Shuo. FOXO1 orchestrates the intestinal homeostasis via neuronal signaling in group 3 innate lymphoid cells. JOURNAL OF EXPERIMENTAL MEDICINE[J]. 2023, 220(10): http://dx.doi.org/10.1084/jem.20230133.
[3] Pingping Zhu, Benyu Liu, Zusen Fan. Noncoding RNAs in tumorigenesis and tumor therapy. FUNDAMENTAL RESEARCH[J]. 2023, 3(5): 692-706, https://doaj.org/article/8573d3fb3f26400fb5b34da5f52e18cf.
[4] Liu, Benyu, Zhang, Lingwei, Zhu, Pingping, Fan, Zusen. Regulation of noncoding RNAs in innate lymphoid cells. CELLULAR & MOLECULAR IMMUNOLOGY. 2023, 20(5): 543-545, http://dx.doi.org/10.1038/s41423-023-00993-3.
[5] pingping zhu, 范祖森. 5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal.. Neuron[J]. 2022, https://pubmed.ncbi.nlm.nih.gov/35550066/.
[6] Xiong, Zhen, Zhu, Xiaoxiao, Geng, Jingjing, Xu, Yuwei, Wu, Runyuan, Li, Cunzhen, Fan, Dongdong, Qin, Xiwen, Du, Ying, Tian, Yong, Fan, Zusen. Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine. IMMUNITY[J]. 2022, 55(4): 686-700, http://dx.doi.org/10.1016/j.immuni.2022.03.001.
[7] 范祖森, Nian Liu. circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription.. Nature Communications[J]. 2022, https://pubmed.ncbi.nlm.nih.gov/35953472/.
[8] Ye, Buqing, Yang, Liuliu, Liu, Benyu, Liu, Nian, Fan, Dongdong, Li, Huimu, Sun, Lei, Du, Ying, Wang, Shuo, Tian, Yong, Fan, Zusen. Induction of functional neutrophils from mouse fibroblasts by thymidine through enhancement of Tet3 activity. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2022, 19(5): 619-633, http://dx.doi.org/10.1038/s41423-022-00842-9.
[9] Zhu, Pingping, Lu, Tiankun, Wu, Jiayi, Fan, Dongdong, Liu, Benyu, Zhu, Xiaoxiao, Guo, Hui, Du, Ying, Liu, Feng, Tian, Yong, Fan, Zusen. Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons. CELL RESEARCH[J]. 2022, 32(6): 555-569, http://dx.doi.org/10.1038/s41422-022-00645-7.
[10] Chen, Zhenzhen, Lu, Tiankun, Huang, Lan, Wang, Zhiwei, Yan, Zhongyi, Guan, Yubo, Hu, Wenjing, Fan, Zusen, Zhu, Pingping. Circular RNA cia-MAF drives self-renewal and metastasis of liver tumor-initiating cells via transcription factor MAFF. JOURNAL OF CLINICAL INVESTIGATION[J]. 2021, 131(19): http://dx.doi.org/10.1172/JCI148020..
[11] Benyu Liu, Nian Liu, Xiaoxiao Zhu, Liuliu Yang, Buqing Ye, Huimu Li, Pingping Zhu, Tiankun Lu, Yong Tian, Zusen Fan. Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m(6)A demethylation of Nr4a1 mRNA. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2021, 18(6): 1412-1424, http://dx.doi.org/10.1038/s41423-021-00680-1.
[12] 范祖森. N1-methyladenosinemethylation 1 in tRNA drives liver tumourigenesis by regulating cholesterol metabolism. Nat Commun. 2021, [13] Gu, Yang, Wang, Yanying, He, Luyun, Zhang, Jiahang, Zhu, Xiaoxiao, Liu, Nian, Wang, Jianyi, Lu, Tiankun, He, Lei, Tian, Yong, Fan, Zusen. Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling. MOLECULAR CANCER[J]. 2021, 20(1): https://doaj.org/article/310ce313ee4c4028940c524a143437d2.
[14] Wang, Yanying, Wang, Jing, Li, Xiaoyu, Xiong, Xushen, Wang, Jianyi, Zhou, Ziheng, Zhu, Xiaoxiao, Gu, Yang, Dominissini, Dan, He, Lei, Tian, Yong, Yi, Chengqi, Fan, Zusen. N-1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism. NATURE COMMUNICATIONS[J]. 2021, 12(1): https://doaj.org/article/13c5a25590da4573bc3cc56bbda89738.
[15] 范祖森. Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signalling.. Mol Cancer. 2021, [16] Ye, Buqing, Yang, Liuliu, Qian, Guomin, Liu, Benyu, Zhu, Xiaoxiao, Zhu, Pingping, Ma, Jing, Xie, Wei, Li, Huimu, Lu, Tianku, Wang, Yanying, Wang, Shuo, Du, Ying, Wang, Zhimin, Jiang, Jing, Li, Jinsong, Fan, Dongdong, Meng, Shu, Wu, Jiayi, Tian, Yong, Fan, Zusen. The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells. EMBO JOURNAL[J]. 2020, 39(13): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327502/.
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[18] Wang, Shuo, Qu, Yuan, Xia, Pengyan, Chen, Yi, Zhu, Xiaoxiao, Zhang, Jing, Wang, Guan, Tian, Yong, Ying, Jianming, Fan, Zusen. Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer. CELL RESEARCH[J]. 2020, 30(7): 610-622, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6760043&detailType=1.
[19] Benyu Liu, Buqing Ye, Xiaoxiao Zhu, Liuliu Yang, Huimu Li, Nian Liu, Pingping Zhu, Tiankun Lu, Luyun He, Yong Tian, Zusen Fan. An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution. NATURE COMMUNICATIONS[J]. 2020, 11(1): 1-14, http://dx.doi.org/10.1038/s41467-020-17944-5.
[20] Xiong, Zhen, Xia, Pengyan, Zhu, Xiaoxiao, Geng, Jingjing, Wang, Shuo, Ye, Buqing, Qin, Xiwen, Qu, Yuan, He, Luyun, Fan, Dongdong, Du, Ying, Tian, Yong, Fan, Zusen. Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis. JOURNAL OF EXPERIMENTAL MEDICINE[J]. 2020, 217(2): https://www.webofscience.com/wos/woscc/full-record/WOS:000523657100013.
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[22] 夏朋延, 王硕, Buqing, Ye, Ying, Du, 李翀, Zhen, Xiong, Yuan, Qu, 范祖森. 环状RNA抑制了cGAS介导的造血干细胞衰竭. 科学新闻[J]. 2019, 79-79, http://lib.cqvip.com/Qikan/Article/Detail?id=75888869504849574850485356.
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[134] 马宝骊, 范祖森. 环孢素A与抗B7—1单克隆抗体联用诱导T淋巴细胞耐受的研究. 中华器官移植杂志[J]. 2000, 21(3): 161-, http://lib.cqvip.com/Qikan/Article/Detail?id=4202375.
[135] 范祖森, 马宝骊. 共刺激对T细胞功能和细胞因子格局的作用. 免疫学杂志[J]. 1999, 15(4): 220-, http://lib.cqvip.com/Qikan/Article/Detail?id=3648045.
[136] 范祖森, 敖世洲. 免疫耐受的基础研究与临床应用. 自然杂志[J]. 1999, 21(2): 77-81, http://lib.cqvip.com/Qikan/Article/Detail?id=3616483.
[137] 范祖森. HLA—G研究进展. 国外医学：分子生物学分册[J]. 1999, 21(1): 49-53, http://lib.cqvip.com/Qikan/Article/Detail?id=3428414.
[138] 敖世洲, 范祖森, 马宝骊. 免疫耐受的形成机制. 生命科学[J]. 1999, 11(4): 160-, http://lib.cqvip.com/Qikan/Article/Detail?id=3698333.
[139] 马宝骊, 王利, 范祖森. B7/CD28和ICAM-1/LFA-1共刺激信号对T及B细胞功能影响的研究. 中华微生物学和免疫学杂志. 1999, 19(6): 485-, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=889312&detailType=1.
[140] 范祖森, 敖世洲. 蛋白质内在信号——控制其在细胞内的运输和定位. 自然杂志[J]. 1999, 21(6): 362-362, http://lib.cqvip.com/Qikan/Article/Detail?id=3876646.
[141] 范祖森, 敖世洲. 细胞周期抑制蛋白p27的研究进展. 生命科学[J]. 1999, 11(5): 2-, http://lib.cqvip.com/Qikan/Article/Detail?id=3649706.
[142] 范祖森, 敖世洲. 肿瘤抑制基因Rb与细胞周期调控研究新进展. 生物化学与生物物理进展[J]. 1999, 26(5): 429-, http://lib.cqvip.com/Qikan/Article/Detail?id=3656320.
[143] 马宝骊, 范祖森. 白细胞介素-10和天花粉蛋白抑制抗原提呈细胞表面分子表达及T-细胞增殖. 中国药理学报[J]. 1999, 20(4): 353-, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=498900&detailType=1.
[144] 柏峻, 范祖森, 王利, 马宝骊. T细胞无能与凋亡关系初探. 中国免疫学杂志[J]. 1999, 15(8): 342-, http://lib.cqvip.com/Qikan/Article/Detail?id=3809115.
[145] 范祖森, 敖世洲. 细胞周期关卡调控与细胞癌变. 自然杂志[J]. 1999, 21(1): 8-11, http://lib.cqvip.com/Qikan/Article/Detail?id=3429336.
[146] 张汉明, 范祖森, 马宝骊. T细胞耐受的诱导及其机理研究. 中华微生物学和免疫学杂志[J]. 1999, 19(5): 387-, http://lib.cqvip.com/Qikan/Article/Detail?id=3779343.
[147] 范祖森, 马宝骊. B7—1单抗和CsA联用诱导人T细胞无能及其特性探讨. 中国肿瘤生物治疗杂志[J]. 1999, 6(2): 102-106, http://lib.cqvip.com/Qikan/Article/Detail?id=3554276.
[148] 范祖森, 马宝骊. 白细胞介素—10和天花粉蛋白抑制抗原提呈细胞表面分子表达及T—细？…. 中国药理学报[J]. 1999, 20(4): 353-357, http://lib.cqvip.com/Qikan/Article/Detail?id=3522295.
[149] 范祖森, 马宝骊. B7／CD28和ICAM—1／LFA—1共刺激信号对T及B细胞功？…. 中华微生物学和免疫学杂志[J]. 1999, 19(6): 485-489, http://lib.cqvip.com/Qikan/Article/Detail?id=3843212.
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[152] 孙汶生, 张庆殷, 范祖森, 马大龙, 狄春辉, 曹容华. IL—1ra对佐剂性关节炎大鼠腹腔Mφ细胞因子诱生的抑制作用. 中国免疫学杂志[J]. 1997, 13(5): 273-, http://lib.cqvip.com/Qikan/Article/Detail?id=2770832.
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（1） 免疫学前沿进展（第2版），免疫学前沿进展（第2版），人民卫生出版社，2011-07，第2作者
（2） 免疫学前沿进展（第1版），免疫学前沿进展（第1版），人民卫生出版社，2009-11，第2作者

   

（1） 免疫应答效应相关蛋白质的生物学功能及其作用机制研究，主持，部委级，2010-01--2014-12
（2） SET蛋白复合体的结构与功能研究，主持，国家级，2009-01--2012-12

已指导学生

侯强  博士研究生  071010-生物化学与分子生物学  

吕红霞  博士研究生  071010-生物化学与分子生物学  

华国强  博士研究生  071010-生物化学与分子生物学  

郭玉明  博士研究生  071010-生物化学与分子生物学  

张红莲  博士研究生  071010-生物化学与分子生物学  

胡德庆  博士研究生  071009-细胞生物学  

刘侃  硕士研究生  071010-生物化学与分子生物学  

吴连锋  博士研究生  071010-生物化学与分子生物学  

石磊  博士研究生  071010-生物化学与分子生物学  

现指导学生

安云鹤  博士研究生  071009-细胞生物学  

王丽  博士研究生  071010-生物化学与分子生物学  

唐海东  博士研究生  071010-生物化学与分子生物学  

王硕  博士研究生  071010-生物化学与分子生物学  

钟超  博士研究生  071010-生物化学与分子生物学  

杨轩  博士研究生  071010-生物化学与分子生物学  

刘圣武  博士研究生  071010-生物化学与分子生物学  

陈俊  博士研究生  071010-生物化学与分子生物学  

郝璐  硕士研究生  071010-生物化学与分子生物学  

杨昭  硕士研究生  071010-生物化学与分子生物学  

李倩  博士研究生  071010-生物化学与分子生物学  

夏朋延  博士研究生  071010-生物化学与分子生物学  

刘本宇  硕士研究生  071010-生物化学与分子生物学  

黄贯岭  硕士研究生  071010-生物化学与分子生物学  

李曼  博士研究生  071010-生物化学与分子生物学  

丁志超  博士研究生  071010-生物化学与分子生物学