090801-水产养殖

鱼类黏膜免疫

2006-09--2009-06   华中农业大学   博士
2003-09--2006-07   华中农业大学   硕士
1998-09--2002-06   山东农业大学   学士

   

2021-03~现在, 中国科学院水生生物研究所, 研究员
2015-01~2021-02,华中农业大学, 教授
2010-02~2014-12,美国宾夕法尼亚大学, 博士后
2009-08~2010-01,中国科学院水生生物研究所, 科研助理

2016-08-05-2020-08-28,省级科技特派员,

水生动物免疫学
水产品品质与卫生检验
水生生物科学进展
水产养殖学概论
水生动物免疫学实验
水产科学研究进展
科学精神与水产研究

   

[1] 徐镇, 于永耀, 翟雪, 徐皓月. 一种恒温养殖系统. CN: CN215454792U, 2022-01-11.
[2] 徐镇, 程高锋, 于永耀, 孔维光. 一种适用于冷水性鱼类的简易疫苗浸泡装置. CN: CN215302366U, 2021-12-28.
[3] 徐镇, 王庆超, 郭倩, 徐皓月, 董昭然. 谷氨酰胺在提高虹鳟生长性能中的应用. CN: CN113598286A, 2021-11-05.
[4] 徐镇. 一种水产养殖装置. ZL202122056616.9, 2021-08-27.

   

[1] Jiafeng Cao, Haoyue Xu, Yongyao Yu, Zhen Xu. Regulatory roles of cytokines in T and B lymphocytes-mediated immunity in teleost fish. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY[J]. 2023, 144: http://dx.doi.org/10.1016/j.dci.2022.104621.
[2] Cao, Jiafeng, Ding, Liguo, Wang, Qingchao, Han, Guangkun, Qin, Dacheng, Cheng, Gaofeng, Dong, Zhaoran, Mu, Qingjiang, Kong, Weiguang, Liu, Xia, Yu, Yongyao, Xu, Zhen. Conserved Role of mTORC1 Signaling in B Cell Immunity in Teleost Fish. JOURNAL OF IMMUNOLOGY[J]. 2022, 209(6): 1095-1107, [3] Dong, ZhaoRan, Mu, QingJiang, Kong, WeiGuang, Qin, DaCheng, Zhou, Yong, Wang, XinYou, Cheng, GaoFeng, Luo, YangZhi, Ai, TaoShan, Xu, Zhen. Gut mucosal immune responses and protective efficacy of oral yeast Cyprinid herpesvirus 2 (CyHV-2) vaccine in Carassius auratus gibelio. FRONTIERS IN IMMUNOLOGY[J]. 2022, 13: http://dx.doi.org/10.3389/fimmu.2022.932722.
[4] Mu, Qingjiang, Dong, Zhaoran, Kong, Weiguang, Wang, Xinyou, Yu, Jiaqian, Ji, Wei, Su, Jianguo, Xu, Zhen. Response of immunoglobulin M in gut mucosal immunity of common carp (Cyprinus carpio) infected with Aeromonas hydrophila. FRONTIERS IN IMMUNOLOGY[J]. 2022, 13: http://dx.doi.org/10.3389/fimmu.2022.1037517.
[5] Ding, Liguo, Han, Guangkun, Wang, Xinyou, Sun, Ruhan, Yu, Yongyao, Xu, Zhen. Gallbladder microbiota in early vertebrates provides evolutionary insights into mucosal homeostasis. FRONTIERS IN IMMUNOLOGY[J]. 2022, 13: http://dx.doi.org/10.3389/fimmu.2022.1020413.
[6] Zhenyu Huang, Mengting Zhan, Gaofeng Cheng, Ruiqi Lin, Xue Zhai, Haiou Zheng, Qingchao Wang, Yongyao Yu, Zhen Xu. IHNV Infection Induces Strong Mucosal Immunity and Changes of Microbiota in Trout Intestine. VIRUSES[J]. 2022, 14: https://doaj.org/article/42ded4ee4cdb40418deaae50ffdb920f.
[7] Yu, Yongyao, Huang, Zhenyu, Kong, Weiguang, Dong, Fen, Zhang, Xiaoting, Zhai, Xue, Cheng, Gaofeng, Zhan, Mengting, Cao, Jiafeng, Ding, Liguo, Han, Guangkun, Takizawa, Fumio, Ding, Yang, Sunyer, J Oriol, Xu, Zhen. Teleost swim bladder, an ancient air-filled organ that elicits mucosal immune responses. CELL DISCOVERY[J]. 2022, 8(1): http://dx.doi.org/10.1038/s41421-022-00393-3.
[8] Meng, KaiFeng, Ding, LiGuo, Wu, Sha, Wu, ZhengBen, Cheng, GaoFeng, Zhai, Xue, Sun, RuHan, Xu, Zhen. Interactions Between Commensal Microbiota and Mucosal Immunity in Teleost Fish During Viral Infection With SVCV. FRONTIERS IN IMMUNOLOGY[J]. 2021, 12: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058427/.
[9] Xu Zhen. Prevailing role of mucosal immunoglobulins and B cells in teleost skin immune responses to bacterial infection.. Journal of Immunology. 2021, [10] Yu, YongYao, Ding, LiGuo, Huang, ZhenYu, Xu, HaoYue, Xu, Zhen. Commensal bacteria-immunity crosstalk shapes mucosal homeostasis in teleost fish. REVIEWS IN AQUACULTUREnull. 2021, 13(4): 2322-2343, http://dx.doi.org/10.1111/raq.12570.
[11] Wang, Qingchao, Ji, Wei, Xu, Zhen. Current use and development of fish vaccines in China. FISH & SHELLFISH IMMUNOLOGY[J]. 2020, 96: 223-234, http://dx.doi.org/10.1016/j.fsi.2019.12.010.
[12] Liu, Xia, Yu, Yongyao, Qin, Dacheng, Song, Zixi, Huang, Zhenyu, Meng, Kaifeng, Cao, Jiafeng, Xu, Fangzheng, Cheng, Gaofeng, Ji, Wei, Xu, Zhen. Expression analysis of taste receptor genes (T1R1, T1R3, and T2R4) in response to bacterial, viral and parasitic infection in rainbow trout, Oncorhynchus mykiss. FISH & SHELLFISH IMMUNOLOGY[J]. 2020, 101: 176-185, http://dx.doi.org/10.1016/j.fsi.2020.03.055.
[13] Dong, Fen, Yin, Guangmei, Meng, Kaifeng, Xu, Haoyue, Liu, Xia, Wang, Qingchao, Xu, Zhen. IgT Plays a Predominant Role in the Antibacterial Immunity of Rainbow Trout Olfactory Organs. FRONTIERS IN IMMUNOLOGY[J]. 2020, 11: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701277/.
[14] Xu, Zhen, Takizawa, Fumio, Casadei, Elisa, Shibasaki, Yasuhiro, Ding, Yang, Sauters, Thomas J C, Yu, Yongyao, Salinas, Irene, Sunyer, J Oriol. Specialization of mucosal immunoglobulins in pathogen control and microbiota homeostasis occurred early in vertebrate evolution. SCIENCE IMMUNOLOGY[J]. 2020, 5(44): https://www.webofscience.com/wos/woscc/full-record/WOS:000519520300004.
[15] Xu Zhen. Mediation of mucosal immunoglobulins in buccal cavity of primitive vertebrate in antibacterial immunity. Frontiers in Immunology. 2020, [16] Yu, Yongyao, Wang, Qingchao, Huang, Zhenyu, Ding, Liguo, Xu, Zhen. Immunoglobulins, Mucosal Immunity and Vaccination in Teleost Fish. FRONTIERS IN IMMUNOLOGYnull. 2020, 11: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566178/.
[17] Kong, Weiguang, Yu, Yongyao, Dong, Shuai, Huang, Zhenyu, Ding, Liguo, Cao, Jiageng, Dong, Fen, Zhang, Xiaoting, Liu, Xia, Xu, Haoyue, Meng, Kaifeng, Su, Jianguo, Xu, Zhen. Pharyngeal Immunity in Early Vertebrates Provides Functional and Evolutionary Insight into Mucosal Homeostasis. JOURNAL OF IMMUNOLOGY[J]. 2019, 203(11): 3054-3067, https://www.webofscience.com/wos/woscc/full-record/WOS:000497950400028.
[18] Xu Zhen. Immune responses of fish to Ichthyophthirius multifiliis (Ich): a model for understanding immunity against extracellular protozoans. Developmental & Comparative Immunology. 2019, [19] Huang, Zhenyu, Yu, Yongyao, Dong, Shuai, Yin, Yaxing, Wang, Qingchao, Yu, Wei, Luo, Yanzhi, Xu, Jie, Zhang, Liqiang, Yu, Yunzhen, Ai, Taoshan, Xu, Zhen. Major histocompatibility complex class IIA and IIB genes of loach (Misgurnus anguillicaudatus): Molecular cloning and expression analysis in response to bacterial and parasitic challenge. AQUACULTURE[J]. 2019, 500: 359-369, http://dx.doi.org/10.1016/j.aquaculture.2018.10.043.
[20] Xu Zhen. Convergent evolution of mucosal immune responses at the buccal cabity of teleost fish. iScience. 2019, [21] Dong, Shuai, Ding, Liguo, Cao, Jiafeng, Liu, Xia, Xu, Haoyue, Meng, Kaifeng, Yu, Yongyao, Wang, Qingchao, Xu, Zhen. Viral-Infected Change of the Digestive Tract Microbiota Associated With Mucosal Immunity in Teleost Fish. FRONTIERS IN IMMUNOLOGY[J]. 2019, 10: https://doaj.org/article/88b3c813081c45939928dac9b8f1ae8a.

   

（ 1 ） 中国科学院率先行动“****”A类项日，现代农业:鱼类黏膜免疫, 主持, 部委级, 2021-01--2023-12
（ 2 ） 鱼类黏膜B细胞吞噬、抗原递呈功能及其 分子机制的研究, 主持, 国家级, 2021-01--2024-12
（ 3 ） 大黄鱼免疫球蛋白IgM和IgT在抗刺激隐核虫感染中的功能研究, 参与, 国家级, 2020-01--2023-12
（ 4 ） 鱼类B和T淋巴细胞在细菌感染过程中的免疫应答规律与互作机制的研究, 主持, 国家级, 2019-01--2022-12
（ 5 ） 水产动物精准营养及其代谢调控机制一水产动物免疫应答的营养调控机制, 主持, 国家级, 2018-12--2022-12
（ 6 ） 水产动物疫病发 生的分子基础与免疫机制病原诱导的适应性免疫应答的细胞与分子机制, 参与, 国家级, 2018-12--2022-12
（ 7 ） 生命科学:鱼类免疫学, 主持, 国家级, 2017-01--2019-12
（ 8 ） 湖北省“楚天学者”主讲教授-华中农业大学高层次人才启动经费、鱼类免疫学, 主持, 省级, 2015-08--2020-06

（1）Adaptive Immunity & Vaccines   2019-11-01
（2）Mucosal Immunoglobulin IgT Plays a Key role In The Oral Immunity of Teleosts   2019-06-16
（3）Mucosal Immunity   2018-06-17