基本信息
张先恩  男  博导  中国科学院生物物理研究所
电子邮件: zhangxe@ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号
邮政编码: 100101

研究领域

微生物学,分析病原微生物学

招生信息

   
招生专业
071010-生物化学与分子生物学
071005-微生物学
招生方向
利用生物大分子识别功能和自组装原理,构建纳米生物传感体系
生物化学与分子生物学

教育背景

1991-09--1994-07   中国科学院微生物研究所   理学博士
1982-09--1985-07   中国科学院武汉病毒研究所   理学硕士
1979-09--1982-07   湖北大学   理学学士
学历
-- 研究生
学位
-- 博士

工作经历

   
工作简历
2013-05~现在, 中国科学院生物物理研究所, 研究员
2002-01~2013-04,科技部基础研究司, 司长
1999-01~2002-01,中国科学院武汉分院, 党组书记,副院长
1996-09~1996-11,英国伦敦帝国理工大学生化系, 高级访问学者
1994-06~1994-12,英国伦敦帝国理工大学生化系, 高级访问学者
1993-01~现在, 中国科学院武汉病毒研究所, 研究员
1993-01~1993-12,美国夏威夷大学, 高级访问学者
1992-01~1999-01,中国科学院武汉病毒研究所, 副所长,学术委员会主任
1989-01~1993-01,中国科学院武汉病毒研究所, 副研究员
1986-01~1987-01,加拿大阿伯达研究院生物工程系, 访问学者
1985-07~1988-12,中国科学院武汉病毒研究所, 实研,助研,课题组长
社会兼职
2014-09-01-今,亚洲生物技术协会,纳米生物技术、生物传感与生物芯片分会共会长,
2011-01-01-2016-12-31,伦敦纳米中心国际顾问委员会, 委员
2010-05-31-今,Biosensors &Bioelectronics, 编委
2009-06-30-2012-10-01,中国生物物理学会, 副理事长
2008-10-01-2016-10-01,中国微生物学会, 副理事长
2008-05-01-2018-04-30,世界生物传感学术大会(两年一度), 组委会中国代表
2003-05-01-今,Biocatalysis & Biotransformation, 编委

教授课程

生命科学导论
“重要生物体系的结构与功能”前沿讲座

专利与奖励

   
奖励信息
(1) 生物传感新原理研究, 一等奖, 省级, 2015
(2) 荣誉科学博士学位, 其他, 2015
(3) 中国科技部首批国家跨世纪人才第一、二层次人选, , 部委级, 1996
(4) 中科院有突出贡献的中青年专家, , 院级, 1994
(5) 中国科学院科技进步奖, 三等奖, 院级, 1989
(6) 首届中科院青年科学家奖, , 院级, 1989
专利成果
( 1 ) 一种高活力葡萄糖氧化酶的编码基因及制备方法和应用, 发明, 2010, 第 2 作者, 专利号: ZL 2007 1 0052783.8
( 2 ) 一种利用生物芯片检测二恶英类化学物质的方法, 发明, 2010, 第 2 作者, 专利号: ZL 2005 1 0019330.6
( 3 ) 单链抗体A1-甲基对硫磷水解酶融合蛋白及其制备方法, 发明, 2008, 第 2 作者, 专利号: ZL 2005 1 0020017.4
( 4 ) 一种检测二恶英的单链抗体方法, 发明, 2007, 第 1 作者, 专利号: ZL 2005 1 0019329.3
( 5 ) 一种高通量监测环境中二恶英类化学物质的方法, 发明, 2007, 第 2 作者, 专利号: ZL 2005 1 0018969.2
( 6 ) 一种纳米分子生物传感器及制备方法和用途, 发明, 2009, 第 3 作者, 专利号: 200910063483.9
( 7 ) 一种葡萄糖氧化酶的编码基因及制备方法和应用, 发明, 2010, 第 2 作者, 专利号: ZL 2007 1 0052784.2
( 8 ) 噬菌体免疫PCR检测病原的方法, 发明, 2008, 第 1 作者, 专利号: ZL 2006 1 0018858.6
( 9 ) 一种枯草芽孢杆菌脂肪酶及制备方法和应用, 发明, 2010, 第 1 作者, 专利号: 201010187107.3
( 10 ) 一种枯草芽孢杆菌脂肪酶及制备方法和应用, 发明, 2010, 第 1 作者, 专利号: 201010187108.8
( 11 ) 结核分枝杆菌吡嗪酰胺耐药性检测的方法, 发明, 2010, 第 5 作者, 专利号: 201010285041.1
( 12 ) 一种定量检测炭疽芽孢的磁性免疫层析试纸条及制备方法, 发明, 2011, 第 1 作者, 专利号: 201110151215.X
( 13 ) 一种结核分枝杆菌全蛋白质芯片及应用, 发明, 2014, 第 1 作者, 专利号: 201410095163.2
( 14 ) 一组结核分枝杆菌蛋白及其编码基因与应用, 发明, 2014, 第 1 作者, 专利号: 201410594400.X

出版信息

   
发表论文
[1] Ke Wang, Yu Pan, Dianbing Wang, Ye Yuan, Min Li, Yuanyuan Chen, Lijun Bi, XianEn Zhang. Altered hACE2 binding affinity and S1/S2 cleavage efficiency of SARS-CoV-2 spike protein mutants affect viral cell entry. VIROLOGICA SINICA[J]. 2023, 38(4): 595-605, http://dx.doi.org/10.1016/j.virs.2023.06.005.
[2] Zhang, XianEn, Liu, Chenli, Dai, Junbiao, Yuan, Yingjin, Gao, Caixia, Feng, Yan, Wu, Bian, Wei, Ping, You, Chun, Wang, Xiaowo, Si, Tong. Enabling technology and core theory of synthetic biology. SCIENCE CHINA-LIFE SCIENCESnull. 2023, 66(8): 1742-1785, http://dx.doi.org/10.1007/s11427-022-2214-2.
[3] Gong, Rui, Yang, Chenyang, Abbas, Ghulam, Wang, Dianbing, Zhang, Xianen, Nie, Guohui, Ding, Hui. Diagnosis of nasopharyngeal carcinoma using an ultrasensitive immunoassay method based on nanoparticles. NANOSCALE[J]. 2023, 15(7): 3475-3481, http://dx.doi.org/10.1039/d2nr05848k.
[4] Abbas, Ghulam, Cui, Mengmeng, Wang, Dianbing, Li, Min, Zhang, XianEn. Construction of Genetically Encoded Biosensors to Monitor Subcellular Compartment-Specific Glutathione Response to Chemotherapeutic Drugs in Acute Myeloid Leukemia Cells. ANALYTICAL CHEMISTRY. 2023, 95(5): 2838-2847, http://dx.doi.org/10.1021/acs.analchem.2c04255.
[5] Tang, Jingya, Zhang, Guimin, Li, Feng, Zeng, Rongyu, Song, Jin, Abbas, Ghulam, Cui, Mengmeng, Zhang, Wei, Zhang, XianEn, Wang, DianBing. Two-Dimensional Protein Nanoarray as a Carrier of Sensing Elements for Gold-Based Immunosensing Systems. ANALYTICAL CHEMISTRY. 2022, [6] Cui, Mengmeng, Abbas, Ghulam, Wang, Dianbing, Liu, Qian, Gong, Rui, Li, Min, Zhang, XianEn. Genetically encoded redox biosensor system for H2O2 measurement in four subcellular compartments in acute myeloid leukemia (AML) cells. SCIENCE CHINA-LIFE SCIENCES[J]. 2022, 65(6): 1259-1262, http://dx.doi.org/10.1007/s11427-021-2049-6.
[7] Ma, Yingxin, Mao, Guobin, Wu, Guoqiang, Zhang, XianEn. Single-Particle Tracking Reveals the Interplay between HIV-1 Reverse Transcription and Uncoating. ANALYTICAL CHEMISTRY[J]. 2022, 94(5): 2648-2654, http://dx.doi.org/10.1021/acs.analchem.1c05199.
[8] Fang, Ti, Li, Chaoqun, Liang, Ao, Zhang, Hui, Zhang, Fan, Zhang, XianEn, Yang, YiYu, Li, Feng. Probing cell membrane integrity using a histone-targeting protein nanocage displaying precisely positioned fluorophores. NANO RESEARCH[J]. 2022, 16: 894-904, http://dx.doi.org/10.1007/s12274-022-4785-5.
[9] Gong, Rui, Wang, Dianbing, Abbas, Ghulam, Li, Shimin, Liu, Qian, Cui, Mengmeng, Zhang, XianEn. A switch-on molecular biosensor for detection of caspase-3 and imaging of apoptosis of cells. SCIENCE CHINA-LIFE SCIENCES[J]. 2022, 65(3): 540-549, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000697090200002.
[10] Chen Chen, Juan Zhou, Dong Men, Xian-En Zhang. Promoter-regulated in vivo asymmetric self-assembly strategy to synthesize heterogeneous nanoparticles for signal amplification. NANOSCALE[J]. 2022, [11] Xiaowei Zhang, Cuiqin Liang, Hanzhong Wang, Zhengyuan Guo, Heng Rong, Jingdi Pan, Wei Li, Rongjuan Pei, Xinwen Chen, Zhiping Zhang, XianEn Zhang, Zongqiang Cui. T-Cell Immunoglobulin and Mucin Domain 1 (TIM-1) Is a Functional Entry Factor for Tick-Borne Encephalitis Virus. MBIO[J]. 2022, 13(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787471/.
[12] Cao, Shanshan, Zhang, Qing, Song, Liu, Xiao, Mingzhong, Chen, Yexing, Wang, Dianbing, Li, Min, Hu, Jinchao, Lin, Lin, Zheng, Ying, Zhou, Kun, Ye, Shujian, Zhou, Juan, Zhou, Ya Na, Cui, Jing, Wang, Jingzhi, Sun, Jing, Tao, Junxiu, Chen, Zhou, Chen, Rong, Zhou, Peng, Shi, Zhengli, Wei, Sheng, Zhao, Linhua, Wang, Hui, Tong, Xiaoling, Li, Xiaodong, Men, Dong, Hou, Baidong, Zhang, XianEn. Dysregulation of Innate and Adaptive Immune Responses in Asymptomatic SARS-CoV-2 Infection with Delayed Viral Clearance. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES[J]. 2022, 18(12): 4648-4657, http://dx.doi.org/10.7150/ijbs.72963.
[13] Mao, Guobin, Wu, Guoqiang, Chen, Minghai, Yan, Chuang, Tang, Jingya, Ma, Yingxin, Zhang, XianEn. Synthesis of Dual-Emitting CdZnSe/Mn:ZnS Quantum Dots for Sensing the pH Change in Live Cells. ANALYTICAL CHEMISTRY[J]. 2022, 94(18): 6665-6671, http://dx.doi.org/10.1021/acs.analchem.1c04811.
[14] Ruimin Gao, Huan Tan, Shanshan Li, Shaojie Ma, Yufu Tang, Kaiming Zhang, Zhiping Zhang, Quli Fan, Jun Yang, XianEn Zhang, Feng Li. A prototype protein nanocage minimized from carboxysomes with gated oxygen permeability. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2022, 119(5): [15] Li, Shimin, Wang, Dianbing, Ghulam, Abbas, Li, Xia, Li, Min, Li, Qin, Ma, Yingxin, Wang, Lei, Wu, Hangshen, Cui, Zongqiang, Zhang, XianEn. Tracking the Replication-Competent Zika Virus with Tetracysteine-Tagged Capsid Protein in Living Cells. JOURNAL OF VIROLOGY[J]. 2022, 96(7): http://dx.doi.org/10.1128/jvi.01846-21.
[16] Zhou, Juan, Men, Dong, Zhang, XianEn. Progress in wearable sweat sensors and their applications. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY[J]. 2022, 50(2): 87-96, http://dx.doi.org/10.1016/j.cjac.2021.11.004.
[17] Heng Rong, Mi Qi, Jingdi Pan, Yuhan Sun, JIawang Gao, Xiaowei Zhang, Wei Li, Bo Zhang, Xian-En Zhang, Zongqiang Cui. Self-Assembling Nanovaccine Confers Complete Protection Against Zika Virus Without Causing Antibody-Dependent Enhancement. FRONTIERS IN IMMUNOLOGY[J]. 2022, 13: 905431-, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124840/.
[18] Song, Jin, Li, Yiwei, Ke, Dingkun, Wang, Dianbing, Zhang, XianEn. In situ graphene-modified carbon microelectrode array biosensor for biofilm impedance analysis. ELECTROCHIMICA ACTA[J]. 2022, 403: http://dx.doi.org/10.1016/j.electacta.2021.139570.
[19] Huang, Lin, Zhou, Mengyang, Abbas, Ghulam, Li, Chao, Cui, Mengmeng, Zhang, XianEn, Wang, DianBing. A Cancer Cell Membrane-Derived Biomimetic Nanocarrier for Synergistic Photothermal/Gene Therapy by Efficient Delivery of CRISPR/Cas9 and Gold Nanorods. ADVANCED HEALTHCARE MATERIALS[J]. 2022, 11(16): http://dx.doi.org/10.1002/adhm.202201038.
[20] Hou, Yu, Wang, Dianbing, Lu, Song, Guo, Dongge, Li, Min, Cui, Mengmeng, Zhang, XianEn. Optogenetic Control of Background Fluorescence Reduction for CRISPR-Based Genome Imaging. ANALYTICAL CHEMISTRY[J]. 2022, 94(24): 8724-8731, http://dx.doi.org/10.1021/acs.analchem.2c01113.
[21] Ma, Yingxin, Mao, Guobin, Yang, Weishan, Wu, Guoqiang, Li, Guoqiang, Li, Xiaoying, Lin, Xin, Lu, Junnan, Zhao, Shijun, Zhao, Wei, Dai, Junbiao, Zhang, XianEn. Studying bona fide SARS-CoV-2 biology in a BSL-2 biosafety environment using a split-virus-genome system. SCIENCE CHINA-LIFE SCIENCESnull. 2022, 65(9): 1894-1897, http://lib.cqvip.com/Qikan/Article/Detail?id=7107979931.
[22] Xiayi Feng, Ding Gao, Yipeng Jing, Junchao Qian, Zongqiang Cui, Juan Zhou, Xian-En Zhang, Dong Men. Intracellular Delivery of Micron-Sized Magnetic Particles through a Virus Infection Pathway. Acs Applied Materials & Interfaces[J]. 2022, [23] Zhou, Xiaoli, Zhou, YaNa, Ali, Ashaq, Liang, Cuiqin, Ye, Zhiqin, Chen, Xiaomin, Zhang, Qing, Deng, Lihua, Sun, Xinyi, Zhang, Qian, Luo, Jihong, Li, Wei, Zhou, Kun, Cao, Shanshan, Zhang, Xiaowei, Li, XiaoDong, Zhang, XianEn, Cui, Zongqiang, Men, Dong. Case Report: A Re-Positive Case of SARS-CoV-2 Associated With Glaucoma. FRONTIERS IN IMMUNOLOGY[J]. 2021, 12: http://dx.doi.org/10.3389/fimmu.2021.701295.
[24] Zheng, Yang, Zhang, Qing, Ali, Ashaq, Li, Ke, Shao, Nan, Zhou, Xiaoli, Ye, Zhiqin, Chen, Xiaomin, Cao, Shanshan, Cui, Jing, Zhou, Juan, Wang, Dianbing, Hou, Baidong, Li, Min, Cui, Mengmeng, Deng, Lihua, Sun, Xinyi, Zhang, Qian, Yang, Qinfang, li, Yong, Wang, Hui, Lei, Yake, Yu, Bo, Cheng, Yegang, Tong, Xiaolin, Men, Dong, Zhang, XianEn. Sustainability of SARS-CoV-2 Induced Humoral Immune Responses in COVID-19 Patients from Hospitalization to Convalescence Over Six Months. VIROLOGICA SINICA[J]. 2021, 36(5): 869-878, http://dx.doi.org/10.1007/s12250-021-00360-4.
[25] Zhu, Weiwei, Fang, Ti, Zhang, Wenjing, Liang, Ao, Zhang, Hui, Zhang, ZhiPing, Zhang, XianEn, Li, Feng. A ROS scavenging protein nanocage for in vitro and in vivo antioxidant treatment. NANOSCALE[J]. 2021, 13(8): 4634-4643, http://dx.doi.org/10.1039/d0nr08878a.
[26] Ma, Yingxin, Mao, Guobin, Wu, Guoqiang, Cui, Zongqiang, Zhang, XianEn, Huang, Weiren. CRISPR-dCas9-Guided and Telomerase-Responsive Nanosystem for Precise Anti-Cancer Drug Delivery. ACS APPLIED MATERIALS & INTERFACES[J]. 2021, 13(7): 7890-7896, http://dx.doi.org/10.1021/acsami.0c19217.
[27] Zhang, Yuwei, Zhou, Juan, Zhang, Yuchen, Liu, Tiangang, Lu, Xiaoyun, Men, Dong, Zhang, XianEn. Auxiliary Module Promotes the Synthesis of Carboxysomes in E. coli to Achieve High-Efficiency CO2 Assimilation. ACS SYNTHETIC BIOLOGY[J]. 2021, 10(4): 707-715, http://dx.doi.org/10.1021/acssynbio.0c00436.
[28] Shi, Hongmei, Li, Ting, Xu, Jintian, Yu, Jifang, Yang, Shanshan, Zhang, XianEn, Tao, Shengce, Gu, Jing, Deng, JiaoYu. MgrB Inactivation Confers Trimethoprim Resistance in Escherichia coli. FRONTIERSINMICROBIOLOGY[J]. 2021, 12: http://dx.doi.org/10.3389/fmicb.2021.682205.
[29] Lu, Song, Wang, Dianbing, Hou, Yu, Guo, Dongge, Deng, Yulin, Zhang, XianEn. Illuminating single genomic loci in live cells by reducing nuclear background fluorescence. SCIENCE CHINA-LIFE SCIENCES[J]. 2021, 64(5): 667-677, https://www.sciengine.com/doi/10.1007/s11427-020-1794-2.
[30] Ma, Yingxin, Mao, Guobin, Wu, Guoqiang, Chen, Minghai, Qin, Fujun, Zheng, Luping, Zhang, XianEn. Dual-Fluorescence Labeling Pseudovirus for Real-Time Imaging of Single SARS-CoV-2 Entry in Respiratory Epithelial Cells. ACS APPLIED MATERIALS & INTERFACES[J]. 2021, 13(21): 24477-24486, http://dx.doi.org/10.1021/acsami.1c03897.
[31] Yang, Yong, Wang, Xi, Du, RongHui, Zhang, Wei, Si, HaoRui, Zhu, Yan, Shen, XuRui, Li, Qian, Li, Bei, Men, Dong, Zhou, Yana, Wang, Hui, Tong, Xiaolin, Zhang, Xianen, Shi, ZhengLi, Zhou, Peng. Serological investigation of asymptomatic cases of SARS-CoV-2 infection reveals weak and declining antibody responses. EMERGING MICROBES & INFECTIONS[J]. 2021, 10(1): 905-912, http://dx.doi.org/10.1080/22221751.2021.1919032.
[32] Li, Xia, Wang, Dianbing, Cui, Zongqiang, Li, Qin, Li, Min, Ma, Yingxin, Hu, Qinxue, Zhou, Yikai, Zhang, XianEn. HIV-1 viral cores enter the nucleus collectively through the nuclear endocytosis-like pathway. SCIENCE CHINA-LIFE SCIENCES[J]. 2021, 64(1): 66-76, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6916199&detailType=1.
[33] Chen, Xiaohua, Zhou, Juan, Chen, Chen, Hou, Baidong, Ali, Ashaq, Li, Feng, Hua, Zhaolin, Wu, Yingtao, Yang, Qin, Chen, Min, Zhang, Rong, Huang, Qianchuan, Ding, Jinya, Zhang, XianEn, Men, Dong. Consecutive Monitoring of Interleukin-6 Is Needed for COVID-19 Patients. VIROLOGICA SINICAnull. 2021, 36(5): 1093-1096, http://dx.doi.org/10.1007/s12250-021-00425-4.
[34] Esmaeili, Chakavak, Song, Jin, Li, Yuliang, Mao, Lanqun, Liu, Huibiao, Wu, Fei, Chen, Yanhuan, Liu, Chenli, Zhang, XianEn. Synthesis and Application of Graphdiyne Oxide-Polyurethane Nanocomposite Yield a Highly Sensitive Non-Enzyme Glucose Sensor. JOURNAL OF THE ELECTROCHEMICAL SOCIETY[J]. 2021, 168(7): http://dx.doi.org/10.1149/1945-7111/ac139c.
[35] Chen, Minghai, Zhang, XianEn. Construction and applications of SARS-CoV-2 pseudoviruses: a mini review. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCESnull. 2021, 17(6): 1574-1580, http://dx.doi.org/10.7150/ijbs.59184.
[36] Zhang, Wenjing, Jia, Qingyan, Teng, Yibo, Yang, Mengsi, Zhang, Hui, Zhang, XianEn, Wang, Pengfei, Ge, Jiechao, Cao, Sheng, Li, Feng. An Ultrastable Virus-Like Particle with a Carbon Dot Core and Expanded Sequence Plasticity. SMALL[J]. 2021, 17(35): http://dx.doi.org/10.1002/smll.202101717.
[37] Ali, Ashaq, Noman, Muhammad, Guo, Yong, Liu, Xu, Zhang, Rong, Zhou, Juan, Zheng, Yang, Zhang, XianEn, Qi, Yong, Chen, Xiaohua, Men, Dong. Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality. SCIENTIFIC REPORTS[J]. 2021, 11(1): http://dx.doi.org/10.1038/s41598-021-85426-9.
[38] Li, Wei, Liu, Ji, Liu, Yuanyuan, Li, Qin, Yin, Wen, Wanderi, Kevin K, Zhang, Xiaowei, Zhang, Zhiping, Zhang, XianEn, Cui, Zongqiang. HIV-1 Uses Dynamic Podosomes for Entry into Macrophages. JOURNAL OF VIROLOGY[J]. 2021, 95(10): https://www.webofscience.com/wos/woscc/full-record/WOS:000647441000001.
[39] Zhang, Jianlin, Li, Shimin, Xie, Ni, Nie, Guohui, Tang, Aifa, Zhang, XianEn, Liang, Minmin, Yan, Xiyun. A natural nanozyme in life is found: the iron core within ferritin shows superoxide dismutase catalytic activity. SCIENCE CHINA-LIFE SCIENCES[J]. 2021, 64(8): 1375-1378, http://dx.doi.org/10.1007/s11427-020-1865-2.
[40] Chen, Minghai, Yan, Chuang, Qin, Fujun, Zheng, Luping, Zhang, XianEn. The intraviral protein-protein interaction of SARS-CoV-2 reveals the key role of N protein in virus-like particle assembly. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES[J]. 2021, 17(14): 3889-3897, http://dx.doi.org/10.7150/ijbs.64977.
[41] Chen, Minghai, Yan, Chuang, Ma, Yingxin, Zhang, XianEn. A tandem near-infrared fluorescence complementation system with enhanced fluorescence for imaging protein-protein interactions in vivo. BIOMATERIALS[J]. 2021, 268: http://dx.doi.org/10.1016/j.biomaterials.2020.120544.
[42] Zhang, Juan, Zhang, Wenjing, Yang, Mengsi, Zhu, Weiwei, Li, Ming, Liang, Ao, Zhang, Hui, Fang, Ti, Zhang, XianEn, Li, Feng. Passive cancer targeting with a viral nanoparticle depends on the stage of tumorigenesis. NANOSCALE[J]. 2021, 13(26): 11334-11342, http://dx.doi.org/10.1039/d1nr01619a.
[43] Gao, Ruimin, Zhang, XianEn, Li, Feng. Generation and characterization of self-assembled protein nanocages based on beta-carboxysomes in Escherichia coli. ACTA BIOCHIMICA ET BIOPHYSICA SINICA[J]. 2021, 53(7): 943-949, http://dx.doi.org/10.1093/abbs/gmab064.
[44] Zheng, Luping, Ma, Yingxin, Chen, Minghai, Wu, Guoqiang, Yan, Chuang, Zhang, XianEn. SARS-CoV-2 spike protein receptor-binding domain N-glycans facilitate viral internalization in respiratory epithelial cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2021, 579: 69-75, http://dx.doi.org/10.1016/j.bbrc.2021.09.053.
[45] Chen, Minghai, Li, Siting, Li, Wei, Zhang, ZhiPing, Zhang, Xiaowei, Zhang, XianEn, Ge, Feng, Cui, Zongqiang. Nanoscale Imaging of RNA-Protein Interactions with a Photoactivatable Trimolecular Fluorescence Complementation System. ACS CHEMICAL BIOLOGY[J]. 2021, 16(6): 1003-1010, http://dx.doi.org/10.1021/acschembio.0c00945.
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[114] Zhang Xianen. Imaging Viral Behaviors in Mammalian Cells with Self-Assembled Capsid-Quantum-Dot Hybrid Particles.. Small. 2009, [115] Liu, Yalan, Cui, Zongqiang, Zhang, Zhiping, Wei, Hongping, Zhou, Yafeng, Wang, Mingli, Zhang, XianEn. The tegument protein UL94 of human cytomegalovirus as a binding partner for tegument protein pp28 identified by intracellular imaging. VIROLOGY[J]. 2009, 388(1): 68-77, http://www.corc.org.cn/handle/1471x/2375599.
[116] Cui, Zongqiang, Zhang, Ke, Zhang, Zhiping, Liu, Yalan, Zhou, Yafeng, Wei, Hongping, Zhang, XianEn. Visualization of the dynamic multimerization of human Cytomegalovirus pp65 in punctuate nuclear foci. VIROLOGY[J]. 2009, 392(2): 169-177, http://www.corc.org.cn/handle/1471x/2375598.
[117] Zhang Xianen. On-chip ligation of multiplexing probe-pairs for identifying point mutations out of dense SNP loci.. Biosens Bioelectron. 2009, [118] Zhang, H, Bi, LJ, Li, CY, Sun, ZG, Deng, JY, Zhang, XE. Mutations Found in the pncA Gene of Mycobacterium tuberculosis in Clinical Pyrazinamide-resistant Isolates from a Local Region of China. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH[J]. 2009, 37(5): 1430-1435, http://dx.doi.org/10.1177/147323000903700517.
[119] Wang, DianBing, Bi, LiJun, Zhang, ZhiPing, Chen, YuanYuan, Yang, RuiFu, Wei, HongPing, Zhou, YaFeng, Zhang, XianEn. Label-free detection of B-anthracis spores using a surface plasmon resonance biosensor. ANALYST[J]. 2009, 134(4): 738-742, http://www.irgrid.ac.cn/handle/1471x/757888.
[120] Wang, DianBing, Yang, Ruifu, Zhang, ZhiPing, Bi, LiJun, You, XiangYu, Wei, HongPing, Zhou, YaFeng, Yu, Ziniu, Zhang, XianEn. Detection of B. anthracis Spores and Vegetative Cells with the Same Monoclonal Antibodies. PLOS ONE[J]. 2009, 4(11): http://www.corc.org.cn/handle/1471x/2375591.
[121] Men, Dong, Guo, YongChao, Zhang, ZhiPing, Wei, Hongping, Zhou, YaFeng, Cui, ZongQiang, Liang, XiaoSheng, Li, Ke, Leng, Yan, You, XiangYu, Zhang, XianEn. Seeding-Induced Self-assembling Protein Nanowires Dramatically Increase the Sensitivity of Immunoassays. NANO LETTERS[J]. 2009, 9(6): 2246-2250, http://www.corc.org.cn/handle/1471x/2375538.
[122] Li, Feng, Liu, Qin, Chen, YuanYuan, Yu, ZiNiu, Zhang, ZhiPing, Zhou, YaFeng, Deng, JiaoYu, Bi, LiJun, Zhang, XianEn. Escherichia coli mismatch repair protein MutL interacts with the clamp loader subunits of DNA polymerase III. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS[J]. 2008, 637(1-2): 101-110, http://dx.doi.org/10.1016/j.mrfmmm.2007.07.008.
[123] Wang, Wei, Cui, ZongQiang, Han, Han, Zhang, ZhiPing, Wei, HongPing, Zhou, YaFeng, Chen, Ze, Zhang, XianEn. Imaging and characterizing influenza A virus mRNA transport in living cells. NUCLEIC ACIDS RESEARCH[J]. 2008, 36(15): 4913-4928, http://www.corc.org.cn/handle/1471x/2375514.
[124] Yang, Wei, Zhou, YaFeng, Dai, HePing, Bi, LiJun, Zhang, ZhiPing, Zhang, XiaoHua, Leng, Yan, Zhang, XianEn. Application of methyl parathion hydrolase (MPH) as a labeling enzyme. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2008, 390(8): 2133-2140, http://www.irgrid.ac.cn/handle/1471x/757700.
发表著作
( 1 ) 基因分析和生物芯片技术, GENE ANALYSIS AND BIOCHIP TECHNIQUE, 湖北科学技术出版社, 2004-01, 第 3 作者
( 2 ) High Technology Decelopment Report, 高技术发展报告, 科学出版社, 2005-03, 第 3 作者
( 3 ) 生物传感器, Biosensor, 化学工业出版社, 2005-08, 第 1 作者
( 4 ) 国际科学技术奖概况, A Survey of International Prizes in Science and Technology, 科学出版社, 2009-09, 第 1 作者

科研活动

   
科研项目
( 1 ) 结核分枝杆菌全蛋白质组芯片的构建及应用研究, 主持, 部委级, 2014-01--2016-12
( 2 ) 分析病原微生物学和生物传感, 主持, 部委级, 2013-05--2017-12
参与会议
(1)分子生物传感与细胞分子影像   参加第二届无标记技术国际研讨会   张先恩   2015-03-11
(2)中国合成生物学研究进展   冷泉港亚洲会议   张先恩   2014-12-02
(3)大会组委会中国代表   第二十四届世界生物传感大会   张先恩   2014-05-27

指导学生

已指导学生

黄旭  博士研究生  071005-微生物学  

崔宗强  博士研究生  071005-微生物学  

董艳杰  博士研究生  071005-微生物学  

游璠  博士研究生  071005-微生物学  

贾艳侠  博士研究生  071005-微生物学  

佀静雪  博士研究生  071005-微生物学  

郭永超  博士研究生  071005-微生物学  

乔岩梅  博士研究生  071005-微生物学  

张华  博士研究生  071005-微生物学  

李永进  博士研究生  071005-微生物学  

谷晶  博士研究生  071005-微生物学  

毕利军  博士研究生  071005-微生物学  

杨薇  博士研究生  071005-微生物学  

祁岑  博士研究生  071005-微生物学  

罗明  博士研究生  071005-微生物学  

王婷娟  博士研究生  071005-微生物学  

李可  博士研究生  071005-微生物学  

李中道  博士研究生  071005-微生物学  

田文武  博士研究生  071005-微生物学  

李峰  博士研究生  071005-微生物学  

吴进军  博士研究生  071005-微生物学  

周盈  博士研究生  071005-微生物学  

尤祥宇  博士研究生  071005-微生物学  

钟天映  博士研究生  071011-生物物理学  

林世强  博士研究生  071011-生物物理学  

任茜  硕士研究生  071010-生物化学与分子生物学  

林秀萍  硕士研究生  071010-生物化学与分子生物学  

尹娟  硕士研究生  071005-微生物学  

王绪德  博士研究生  071010-生物化学与分子生物学  

李茹  博士研究生  071010-生物化学与分子生物学  

张敏  博士研究生  071010-生物化学与分子生物学  

刘雅兰  博士研究生  071010-生物化学与分子生物学  

韩昱  硕士研究生  071010-生物化学与分子生物学  

杨仁斌  博士研究生  071010-生物化学与分子生物学  

杨明章  博士研究生  071010-生物化学与分子生物学  

门冬  博士研究生  071010-生物化学与分子生物学  

李风云  博士研究生  071010-生物化学与分子生物学  

梁晓声  博士研究生  071010-生物化学与分子生物学  

程芳  博士研究生  071010-生物化学与分子生物学  

顾佳  硕士研究生  071010-生物化学与分子生物学  

曾德军  硕士研究生  071010-生物化学与分子生物学  

高丁  博士研究生  071010-生物化学与分子生物学  

李昭阳  博士研究生  071010-生物化学与分子生物学  

李坤  博士研究生  071005-微生物学  

李阿茜  博士研究生  071010-生物化学与分子生物学  

田博  硕士研究生  430139-生物工程  

赵亮  硕士研究生  071010-生物化学与分子生物学  

刘凤英  博士研究生  071005-微生物学  

张晓莉  博士研究生  071005-微生物学  

王霆  博士研究生  071005-微生物学  

王明  博士研究生  071010-生物化学与分子生物学  

郝倩  硕士研究生  071005-微生物学  

宋双  硕士研究生  071005-微生物学  

陈涛  博士研究生  071010-生物化学与分子生物学  

黄荔  博士研究生  071005-微生物学  

陈秀秀  硕士研究生  071005-微生物学  

孙曼銮  博士研究生  071005-微生物学  

李敏  硕士研究生  085238-生物工程  

刘冲  硕士研究生  071005-微生物学  

现指导学生

孙宪迅  博士研究生  071005-微生物学  

印文  博士研究生  071005-微生物学  

陈媛媛  博士研究生  071010-生物化学与分子生物学  

郭冬各  博士研究生  071005-微生物学  

王继刚  博士研究生  071005-微生物学  

侯宇  硕士研究生  071010-生物化学与分子生物学  

陈明海  博士研究生  071005-微生物学  

王婷婷  博士研究生  071010-生物化学与分子生物学  

周昆  硕士研究生  071010-生物化学与分子生物学  

曹姗姗  硕士研究生  071010-生物化学与分子生物学  

陈晨  博士研究生  071010-生物化学与分子生物学  

席艳  博士研究生  071010-生物化学与分子生物学  

银芳  硕士研究生  085238-生物工程  

李士敏  博士研究生  071010-生物化学与分子生物学  

李一苇  博士研究生  071010-生物化学与分子生物学  

张玉威  博士研究生  071010-生物化学与分子生物学