基本信息

唐铁山 男 博导 动物研究所
电子邮件:tangtsh@ioz.ac.cn
通信地址:北京市朝阳区北辰西路1号院5号,中国科学院动物研究所,膜生物学国家重点实验室
邮政编码:100101

研究领域

主要研究方向:
1.神经发育性和神经退行性疾病的分子机制
2.神经发育、衰老与神经再生

招生信息

   
招生专业
071009-细胞生物学
招生方向
神经退行性疾病的分子机理

教育背景

1994-09--1998-06 中国科学院发育生物学研究所(现为遗传发育生物学研究所) 博士
1986-09--1994-07 西北农业大学(现为西北农林科技大学) 学士、硕士
学历
-- 研究生
学位
-- 博士

工作经历

   
工作简历
2009-02--今 中国科学院动物研究所 研究员
2006-07--2009-02 美国德州大学西南医学研究中心 讲师
2004-07--2006-07 美国德州大学西南医学研究中心 助理讲师
2000-07--2004-07 美国德州大学西南医学研究中心 博士后
1998-07--2000-07 中国科学院发育生物学研究所(现为遗传发育生物学研究所) 助理研究员
社会兼职
2012-01--今 美国生化与分子生物学学会,会员
2011-01--今 《神经药理学报》编委会编委
2010-05--今 中国老年学学会衰老与抗衰老科学委员会理事
2003-09--今 国际神经科学学会会员

教授课程

细胞生物学技术及应用
再生医学导论
发育生物学
生理学
医学生理学
分子细胞生物学进展

专利与奖励

   
专利成果
[1] 唐铁山, 郭彩霞, 周博, 张传超, 姚富文, 谷峰, 马勇杰. CTD-2256P15.2及其编码微肽作为靶点在开发肿瘤治疗药物中的应用. CN: CN114042160A, 2022-02-15.

出版信息

   
发表论文
[1] Song Zhao, Haiping Feng, Dongfang Jiang, Keyan Yang, Si-Tong Wang, Yu-Xin Zhang, Yun Wang, Hongmei Liu, Caixia Guo, Tie-Shan Tang. ER Ca 2+ overload activates the IRE1α signaling and promotes cell survival. CELL & BIOSCIENCE[J]. 2023, 13(1): 1-19, http://dx.doi.org/10.1186/s13578-023-01062-y.
[2] Ren, JianPing, Cong, HaoLong, Gao, LiJie, Jiang, DongFang, Li, XinTong, Wang, Yun, Wang, JiuQiang, Tang, TieShan. Cyclin-dependent kinase 5 negatively regulates antiviral immune response by disrupting myeloid differentiation primary response protein 88 self-association. VIRULENCE[J]. 2023, 14(1): http://dx.doi.org/10.1080/21505594.2023.2223394.
[3] Dongfang Jiang, Tingting Li, Caixia Guo, Tie-Shan Tang, Hongmei Liu. Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration. CELL & BIOSCIENCE[J]. 2023, 13(1): 1-32, https://doaj.org/article/a2bb3638668f4246b44f5c7bd12dbb49.
[4] Yang, KeYan, Zhao, Song, Feng, Haiping, Shen, Jiaqi, Chen, Yuwei, Wang, SiTong, Wang, SiJia, Zhang, YuXin, Wang, Yun, Guo, Caixia, Liu, Hongmei, Tang, TieShan. Ca2+ homeostasis maintained by TMCO1 underlies corpus callosum development via ERK signaling. CELL DEATH & DISEASE[J]. 2022, 13(8): http://dx.doi.org/10.1038/s41419-022-05131-x.
[5] Xiaolu Ma, Chen Wang, Bo Zhou, Zina Cheng, Zhiyong Mao, TieShan Tang, Caixia Guo. DNA polymerase η promotes nonhomologous end joining upon etoposide exposure dependent on the scaffolding protein Kap1. THE JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2022, 298(5): [6] Li, Xiaoling, Cao, Guanghui, Liu, Xiaokang, Tang, TieShan, Guo, Caixia, Liu, Hongmei. Polymerases and DNA Repair in Neurons: Implications in Neuronal Survival and Neurodegenerative Diseases. FRONTIERS IN CELLULAR NEUROSCIENCE[J]. 2022, 16: http://dx.doi.org/10.3389/fncel.2022.852002.
[7] Zheng, Shanliang, Zhao, Dong, Hou, Guixue, Zhao, Song, Zhang, Wenxin, Wang, Xingwen, Li, Li, Lin, Liang, Tang, TieShan, Hu, Ying. iASPP suppresses Gp78-mediated TMCO1 degradation to maintain Ca2+ homeostasis and control tumor growth and drug resistance. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2022, 119(6): http://dx.doi.org/10.1073/pnas.2111380119.
[8] Zhang, Chuanchao, Zhou, Bo, Gu, Feng, Liu, Hongmei, Wu, Honglin, Yao, Fuwen, Zheng, Hui, Fu, Hui, Chong, Wei, Cai, Shurui, Huang, Min, Ma, Xiaolu, Guo, Zhifang, Li, Tingting, Deng, Wenyuan, Zheng, Meiwen, Ji, Qiao, Zhao, Yongliang, Ma, Yongjie, Wang, QiEn, Tang, TieShan, Guo, Caixia. Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation. MOLECULAR CELL[J]. 2022, 82(7): 1297-+, http://dx.doi.org/10.1016/j.molcel.2022.01.020.
[9] Wang, Jianli, Gong, Juanjuan, Wang, Qiaochu, 唐铁山, Li, Wei. VDAC1 negatively regulates melanogenesis through the Ca2+-calcineurin-CRTC1-MITF pathway.. Life Sci Alliance[J]. 2022, [10] Tingting Li, Hongmei Liu, Dongfang Jiang, Keyan Yang, Jiaqi Shen, Haiping Feng, Sijia Wang, Yuxin Zhang, Yun Wang, TieShan Tang. BMP4 Exerts Anti-Neurogenic Effect via Inducing Id3 during Aging. BIOMEDICINES[J]. 2022, 10: [11] Ta, Na, Qu, Chuanren, Wu, Hao, Zhang, Di, Sun, Tiantian, Li, Yanjun, Wang, Jun, Wang, Xiaohui, Tang, TieShan, Chen, Quan, Liu, Lei. Mitochondrial outer membrane protein FUNDC2 promotes ferroptosis and contributes to doxorubicin-induced cardiomyopathy.. Proc Natl Acad Sci USA.[J]. 2022, [12] Gao, SanHui, Wang, GuiZhen, Wang, LiPeng, Feng, Lin, Zhou, YongChun, Yu, XianJun, Liang, Fan, Yang, FuYing, Wang, Zheng, Sun, BeiBei, Wang, Di, Liang, LiJun, Xie, DaWei, Zhao, Song, Feng, HaiPing, Li, Xueqing, Li, Keqin Kathy, Tang, TieShan, Huang, YunChao, Wang, ShiQiang, Zhou, GuangBiao. Mutations and clinical significance of calcium voltage-gated channel subunit alpha 1E (CACNA1E) in non-small cell lung cancer. CELL CALCIUM[J]. 2022, 102: http://dx.doi.org/10.1016/j.ceca.2022.102527.
[13] Meng, TieGang, Lei, WenLong, Lu, Xukun, Liu, XiaoYu, Ma, XueShan, Nie, XiaoQing, Zhao, ZhengHui, Li, QianNan, Huang, Lin, Hou, Yi, Ouyang, YingChun, Li, Lei, Tang, TieShan, Schatten, Heide, Xie, Wei, Gao, ShaoRong, Ou, XiangHong, Wang, ZhenBo, Sun, QingYuan. Maternal EHMT2 is essential for homologous chromosome segregation by regulating Cyclin B3 transcription in oocyte meiosis. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES[J]. 2022, 18(11): 4513-4531, [14] Daniel J Klionsky, Amal Kamal AbdelAziz, TieShan Tang. GUIDELINES FOR THE USE AND INTERPRETATION OF ASSAYS FOR MONITORING AUTOPHAGY (4TH EDITION). AUTOPHAGY[J]. 2021, 17(1): 1-382, http://dx.doi.org/10.1080/15548627.2020.1797280.
[15] Ma, Xiaolu, Tang, TieShan, Guo, Caixia. Regulation of translesion DNA synthesis in mammalian cells. ENVIRONMENTAL AND MOLECULAR MUTAGENESISnull. 2020, 61(7): 680-692, http://dx.doi.org/10.1002/em.22359.
[16] Tu, Yingfeng, Li, Xiaoling, Zhu, Xuefei, Liu, Xiaokang, Guo, Caixia, Jia, Da, Tang, TieShan. Determining the Fate of Neurons in SCA3: ATX3, a Rising Decision Maker in Response to DNA Stresses and Beyond. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY[J]. 2020, 8: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793700/.
[17] Si Wang, Zheying Min, Qianzhao Ji, Lingling Geng, Yao Su, Zunpeng Liu, Huifang Hu, Lixia Wang, Weiqi Zhang, Keiichiro Suzuiki, Yu Huang, Puyao Zhang, TieShan Tang, Jing Qu, Yang Yu, GuangHui Liu, Jie Qiao. Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction. PROTEIN[J]. 2020, 11(1): http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SSJD8B1D18F153642D8A95C3C50D75628947&DbName=SSJDLAST&DbCode=SSJD&yx=&pr=&URLID=&bsm=.
[18] Wang, JiuQiang, Zhu, Shu, Wang, Yihan, Wang, Fengli, An, Chaoqiang, Jiang, Dongfang, Gao, Lijie, Tu, Yingfeng, Zhu, Xuefei, Wang, Yun, Liu, Hongmei, Gong, Juanjuan, Sun, Zhongshuai, Wang, Xi, Liu, Leimei, Yang, Keyan, Guo, Caixia, Tang, TieShan. Miro2 supplies a platform for Parkin translocation to damaged mitochondria. SCIENCE BULLETIN[J]. 2019, 64(11): 730-747, http://lib.cqvip.com/Qikan/Article/Detail?id=7002267104.
[19] Wang, Xi, Wang, QiaoChu, Sun, Zhongshuai, Li, Tingting, Yang, Keyan, An, Chaoqiang, Guo, Caixia, Tan, TieShan. ER stress mediated degradation of diacylglycerol acyltransferase impairs mitochondrial functions in TMCO1 deficient cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2019, 512(4): 914-920, http://dx.doi.org/10.1016/j.bbrc.2019.03.115.
[20] 唐铁山. 多聚谷氨酰胺神经疾病的表观谱. Epigenomics. 2018, [21] Sun, Zhongshuai, Zhang, Hui, Wang, Xi, Wang, QiaoChu, Zhang, Chuanchao, Wang, JiuQiang, Wang, YiHan, An, ChaoQiang, Yang, KeYan, Wang, Yun, Gao, Fei, Guo, Caixia, Tang, TieShan. TMCO1 is essential for ovarian follicle development by regulating ER Ca2+ store of granulosa cells. CELL DEATH AND DIFFERENTIATION[J]. 2018, 25(9): 1686-1701, https://www.webofscience.com/wos/woscc/full-record/WOS:000444813500012.
[22] Wang, QiaoChu, Wang, Xi, Tang, TieShan. EB1 traps STIM1 and regulates local store-operated Ca2+ entry. JOURNAL OF CELL BIOLOGYnull. 2018, 217(6): 1895-1897, https://www.webofscience.com/wos/woscc/full-record/WOS:000438077800006.
[23] Huang, Min, Zhou, Bo, Gong, Juanjuan, Xing, Lingyu, Ma, Xiaolu, Wang, Fengli, Wu, Wei, Shen, Hongyan, Sun, Chenyi, Zhu, Xuefei, Yang, Yeran, Sun, Yazhou, Liu, Yang, Tang, TieShan, Guo, Caixia. RNA-splicing factor SART3 regulates translesion DNA synthesis. NUCLEIC ACIDS RESEARCH[J]. 2018, 46(9): 4560-4574, https://www.webofscience.com/wos/woscc/full-record/WOS:000433056900024.
[24] Zhu Shu, Tang TieShan. DNA Damage Response and The Pathogenesis of Huntington's Disease. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2017, 44(9): 727-736, [25] 唐铁山. RNA结合蛋白RBM45与HDAC1在FUS介导的DNA损伤应答通路中的作用. Nucleic Acids Res.. 2017, [26] 唐铁山. 睾丸热应激诱导的蛋白乙酰化组学分析. Biochim Biophys Acta. 2017, [27] 唐铁山. 聚合酶Polη的O-GlcNAc化在调控跨损伤DNA修复中的关键作用. Nat Commun. 2017, [28] 王翘楚, 郑巧霞, HaiYan Tan, Bing Zhang, 李晓玲, YuXiu Yang, 王茜, 王久强, 朱姝, 王凤丽, 陈佺, 周爱民, 唐铁山. TMCO1是内质网钙离子过载激活的钙离子通道. 科学新闻[J]. 2017, 34-34, http://lib.cqvip.com/Qikan/Article/Detail?id=672078028.
[29] 唐铁山. 去泛素化酶Ataxin-3通过稳定Chk1促进基因组稳定性. NUCLEICACIDSRES. 2017, [30] 唐铁山. Parkin调控DNA跨损伤合成. Oncotarget. 2017, [31] Zhu Shu, Tang TieShan. DNA Damage Response and The Pathogenesis of Huntington's Disease. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2017, 44(9): 727-736, https://www.webofscience.com/wos/woscc/full-record/WOS:000411657900001.
[32] Xiaolu Ma, Hongmei Liu, Jing Li, Yihao Wang, YueHe Ding, Hongyan Shen, Yeran Yang, Chenyi Sun, Min Huang, Yingfeng Tu, Yang Liu, Yongliang Zhao, MengQiu Dong, Ping Xu, TieShan Tang, Caixia Guo. Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis. NATURE COMMUNICATIONS[J]. 2017, 8(1): 1-14, https://doaj.org/article/9c616037527e4325a52ab77be0fcb10e.
[33] 唐铁山. 亨廷顿基因缺失导致小鼠精子发生阻断和雄性不育. Journal of Cell Science. 2016, [34] Song, Pingping, Li, Shanshan, Wu, Hao, Gao, Ruize, Rao, Guanhua, Wang, Dongmei, Chen, Ziheng, Ma, Biao, Wang, Hongxia, Sui, Nan, Deng, Haiteng, Zhang, Zhuohua, Tang, Tieshan, Tan, Zheng, Han, Zehan, Lu, Tieyuan, Zhu, Yushan, Chen, Quan. Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease. PROTEIN & CELL[J]. 2016, 7(2): 114-129, http://dx.doi.org/10.1007/s13238-015-0230-9.
[35] 唐铁山. Rev1通过泛素化的RAD18促进PCNA的单泛素化. Journal of Cell Science. 2016, [36] Yan, Jinting, Zhang, Hui, Liu, Yang, Zhao, Feilong, Zhu, Shu, Xie, Chengmei, Tang, TieShan, Guo, Caixia. Germline deletion of huntingtin causes male infertility and arrested spermiogenesis in mice. JOURNAL OF CELL SCIENCE[J]. 2016, 129(3): 492-501, https://www.webofscience.com/wos/woscc/full-record/WOS:000369505600006.
[37] Sun, Yazhou, Yang, Yeran, Shen, Hongyan, Huang, Min, Wang, Zhifeng, Liu, Yang, Zhang, Hui, Tang, TieShan, Guo, Caixia. iTRAQ-based chromatin proteomic screen reveals CHD4-dependent recruitment of MBD2 to sites of DNA damage. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2016, 471(1): 142-148, https://www.webofscience.com/wos/woscc/full-record/WOS:000372135200024.
[38] 唐铁山. 三型脊髓小脑共济失调症蛋白Ataxin-3对p53的功能调控. PLoS Biol. 2016, [39] Pingping Song, Shanshan Li, Hao Wu, Ruize Gao, Guanhua Rao, Dongmei Wang, Ziheng Chen, Biao Ma, Hongxia Wang, Nan Sui, Haiteng Deng, Zhuohua Zhang, Tieshan Tang, Zheng Tan, Zehan Han, Tieyuan Lu, Yushan Zhu, Quan Chen. Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease. 蛋白质与细胞:英文版[J]. 2016, 114-129, http://lib.cqvip.com/Qikan/Article/Detail?id=668213973.
[40] 唐铁山. Endophilin B2通过与B1形成异源二聚体促进线粒体自噬过程中的线粒体内膜降解. Sci Rep. 2016, [41] 唐铁山. TMCO1是内质网钙库钙过载激活的钙通道. Cell. 2016, [42] Wang, Zhifeng, Huang, Min, Ma, Xiaolu, Li, Huiming, Tang, Tieshan, Guo, Caixia. REV1 promotes PCNA monoubiquitylation through interacting with ubiquitylated RAD18. JOURNAL OF CELL SCIENCE[J]. 2016, 129(6): 1223-1233, https://www.webofscience.com/wos/woscc/full-record/WOS:000372306700013.
[43] Wang, YiHan, Wang, JiuQiang, Wang, Qiaochu, Wang, Yun, Guo, Caixia, Chen, Quan, Chai, Tuanyao, Tang, TieShan. Endophilin B2 promotes inner mitochondrial membrane degradation by forming heterodimers with Endophilin B1 during mitophagy. SCIENTIFIC REPORTS[J]. 2016, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000375065800001.
[44] Yang, Yeran, Liu, Zhenbo, Wang, Fengli, Temviriyanukul, Piya, Ma, Xiaolu, Tu, Yingfeng, Lv, Lingna, Lin, YuFen, Huang, Min, Zhang, Ting, Pei, Huadong, Chen, Benjamin P C, Jansen, Jacob G, de Wind, Niels, Fischhaber, Paula L, Friedberg, Errol C, Tang, TieShan, Guo, Caixia. FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress. NUCLEIC ACIDS RESEARCH[J]. 2015, 43(17): 8325-8339, https://www.webofscience.com/wos/woscc/full-record/WOS:000366404600024.
[45] 唐铁山. CSB-PGBD3突变导致卵巢功能早衰. PLoS Genet. 2015, [46] Li, Xiaoling, Liu, Hongmei, Fischhaber, Paula L, Tang, TieShan. Toward therapeutic targets for SCA3: Insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance. PROGRESS IN NEUROBIOLOGY[J]. 2015, 132: 34-58, http://dx.doi.org/10.1016/j.pneurobio.2015.06.004.
[47] 唐铁山. 三型脊髓小脑共济失调症蛋白参与非正常折叠蛋白的清除. Progress in Neurobiology. 2015, [48] Xie, Wenjuan, Wang, JiuQiang, Wang, QiaoChu, Wang, Yun, Yao, Sheng, Tang, TieShan. Adult neural progenitor cells from Huntington's disease mouse brain exhibit increased proliferation and migration due to enhanced calcium and ROS signals. CELL PROLIFERATION[J]. 2015, 48(5): 517-531, https://www.webofscience.com/wos/woscc/full-record/WOS:000360725800004.
[49] Qin, Yingying, Guo, Ting, Li, Guangyu, Tang, TieShan, Zhao, Shidou, Jiao, Xue, Gong, Juanjuan, Gao, Fei, Guo, Caixia, Simpson, Joe Leigh, Chen, ZiJiang. CSB-PGBD3 Mutations Cause Premature Ovarian Failure. PLOS GENETICS[J]. 2015, 11(7): https://doaj.org/article/110cf859ffa546f0995ea223081631c0.
[50] 唐铁山. FANCD2和REV1协同保护DNA损伤反应过程中的新生DNA链. Nucleic Acids Res.. 2015, [51] 唐铁山. 亨廷顿氏疾病的成体神经前体细胞具有更强的依赖于钙信号和超氧信号的增殖和迁移能力. Cell Proliferation. 2015, [52] 黄敏, 唐铁山, 郭彩霞. 跨损伤DNA合成及其在肿瘤治疗中的应用. 神经药理学报[J]. 2014, 4(5): 36-43, http://lib.cqvip.com/Qikan/Article/Detail?id=665425904.
[53] 唐铁山. 硫柳汞对新生小鼠脑损伤的转录组学分析. Toxicological Sciences. 2014, [54] Gao, Min, Wei, Wei, Li, MingMing, Wu, YongSheng, Ba, Zhaoqing, Jin, KangXuan, Li, MiaoMiao, Liao, YouQi, Adhikari, Samir, Chong, Zechen, Zhang, Ting, Guo, CaiXia, Tang, Tieshan, Zhu, BingTao, Xu, XingZhi, Mailand, Niels, Yang, YunGui, Qi, Yijun, Danielsen, Jannie M Rendtlew. Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination. CELL RESEARCH[J]. 2014, 24(5): 532-541, https://www.webofscience.com/wos/woscc/full-record/WOS:000335914700003.
[55] Li, Xiaoling, Qu, Fengqin, Xie, Wenjuan, Wang, Fengli, Liu, Hongmei, Song, Shuhui, Chen, Tingting, Zhang, Yang, Zhu, Shu, Wang, Yun, Guo, Caixia, Tang, TieShan. Transcriptomic Analyses of Neurotoxic Effects in Mouse Brain After Intermittent Neonatal Administration of Thimerosal. TOXICOLOGICAL SCIENCES[J]. 2014, 139(2): 452-465, https://www.webofscience.com/wos/woscc/full-record/WOS:000337075900016.
[56] Liu, Yang, Yang, Yeran, Tang, TieShan, Zhang, Hui, Wang, Zhifeng, Friedberg, Errol, Yang, Wei, Guo, Caixia. Variants of mouse DNA polymerase. reveal a mechanism of efficient and accurate translesion synthesis past a benzoa pyrene dG adduct. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2014, 111(5): 1789-1794, https://www.webofscience.com/wos/woscc/full-record/WOS:000330587600043.
[57] 唐铁山. 表观修饰可作为亨廷顿氏神经退行性疾病的治疗靶标. Epigenomics. 2014, [58] Wang, Fengli, Fischhaber, Paula L, Guo, Caixia, Tang, TieShan. Epigenetic modifications as novel therapeutic targets for Huntington's disease. EPIGENOMICS[J]. 2014, 6(3): 287-297, https://www.webofscience.com/wos/woscc/full-record/WOS:000340668300011.
[59] 唐铁山. DNA聚合酶κ参与跨越benzo[a]pyrene dG损伤的机制研究. Proc Natl Acad Sci USA.. 2014, [60] 唐铁山. 线粒体钙信号和超氧信号紊乱与亨廷顿氏舞蹈病线粒体的基因组损伤. J Biol Chem. 2013, [61] Wang, Fengli, Yang, Yeran, Lin, Xiwen, Wang, JiuQiang, Wu, YongSheng, Xie, Wenjuan, Wang, Dandan, Zhu, Shu, Liao, YouQi, Sun, Qinmiao, Yang, YunGui, Luo, HuaiRong, Guo, Caixia, Han, Chunsheng, Tang, TieShan. Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntingtons disease. HUMANMOLECULARGENETICS[J]. 2013, 22(18): 3641-3653, http://www.irgrid.ac.cn/handle/1471x/730359.
[62] 唐铁山. 脑5羟甲基化信号丢失是亨廷顿氏舞蹈病的一个新的表观修饰特征. HUMANMOLECULARGENETICS. 2013, [63] 唐铁山. DNA聚合酶Kappa参与DNA链断裂损伤的功能修复. DNA Repair. 2013, [64] Lv, Lingna, Wang, Fengli, Ma, Xiaolu, Yang, Yeran, Wang, Zhifeng, Liu, Hongmei, Li, Xiaoling, Liu, Zhenbo, Zhang, Ting, Huang, Min, Friedberg, Errol C, Tang, TieShan, Guo, Caixia. Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation. NUCLEIC ACIDS RESEARCH[J]. 2013, 41(22): 10312-10322, https://www.webofscience.com/wos/woscc/full-record/WOS:000329874400031.
[65] Zhang, Xiuli, Lv, Lingna, Chen, Qian, Yuan, Fenghua, Zhang, Ting, Yang, Yeran, Zhang, Hui, Wang, Yun, Jia, Yan, Qian, Liangyue, Chen, Benjamin, Zhang, Yanbin, Friedberg, Errol C, Tang, TieShan, Guo, Caixia. Mouse DNA polymerase kappa has a functional role in the repair of DNA strand breaks. DNA REPAIR[J]. 2013, 12(5): 377-388, http://dx.doi.org/10.1016/j.dnarep.2013.02.008.
[66] Wang, JiuQiang, Chen, Qian, Wang, Xianhua, Wang, QiaoChu, Wang, Yun, Cheng, HePing, Guo, Caixia, Sun, Qinmiao, Chen, Quan, Tang, TieShan. Dysregulation of Mitochondrial Calcium Signaling and Superoxide Flashes Cause Mitochondrial Genomic DNA Damage in Huntington Disease. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2013, 288(5): 3070-3084, http://dx.doi.org/10.1074/jbc.M112.407726.
[67] Zhao, Yuanyuan, Sun, Xiaofeng, Nie, Xuanli, Sun, Liwei, Tang, TieShan, Chen, Dahua, Sun, Qinmiao. COX5B Regulates MAVS-mediated Antiviral Signaling through Interaction with ATG5 and Repressing ROS Production. PLOS PATHOGENS[J]. 2012, 8(12): https://doaj.org/article/ede3883459104d76bff450c3bd5eddf8.
[68] 王久强, 朱姝, 朱雪霏, 郭彩霞, 唐铁山. 线粒体功能异常与亨廷顿舞蹈病的病理发生机制. 神经药理学报[J]. 2012, 1(4): 47-57, http://lib.cqvip.com/Qikan/Article/Detail?id=661684615.
[69] 唐铁山. PARP1在DNA损伤反应中的作用及其肿瘤治疗. Front Med.. 2012, [70] Wang Zhifeng, Wang Fengli, Tang Tieshan, Guo Caixia. The role of PARP1 in the DNA damage response and its application in tumor therapy. FRONTIERS OF MEDICINE[J]. 2012, 6(2): 156-164,  https://search.proquest.com/docview/1941922326.
[71] Lue LingNa, Tang TieShan, Guo CaiXia. Advances of Study on Translesion DNA Synthesis Polymerase kappa in Mammalian Cells. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2011, 38(3): 204-209, https://www.webofscience.com/wos/woscc/full-record/WOS:000288835700002.
[72] Lue LingNa, Tang TieShan, Guo CaiXia. Advances of Study on Translesion DNA Synthesis Polymerase kappa in Mammalian Cells. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2011, 38(3): 204-209, https://www.webofscience.com/wos/woscc/full-record/WOS:000288835700002.
[73] 唐铁山. Tetrabenazine对舞蹈病模型小鼠神经元的保护作用. Molecular Neurodegeneration. 2010, [74] 唐铁山. 快照:核苷酸切除修复. Cell. 2010, [75] Guo, Caixia, Tang, TieShan, Friedberg, Errol C. SnapShot: Nucleotide Excision Repair. CELL. 2010, 140(5): 754-U169, http://dx.doi.org/10.1016/j.cell.2010.02.033.
[76] Wang, Hongyu, Chen, Xi, Li, Yuemei, Tang, TieShan, Bezprozvanny, Ilya. Tetrabenazine is neuroprotective in Huntington's disease mice. MOLECULAR NEURODEGENERATION[J]. 2010, 5(1): http://dx.doi.org/10.1186/1750-1326-5-18.
[77] 唐铁山. 钙信号紊乱与二型小脑脊髓共济失调病神经元的退化. The Journal of Neuroscience. 2009, [78] Guo, Caixia, KosarekStancel, J Nicole, Tang, TieShan, Friedberg, Errol C. Y-family DNA polymerases in mammalian cells. CELLULAR AND MOLECULAR LIFE SCIENCES[J]. 2009, 66(14): 2363-2381, https://www.webofscience.com/wos/woscc/full-record/WOS:000267886500012.
[79] 唐铁山. 三磷酸肌醇受体的碳端短肽片段可以阻止舞蹈病纹状体神经细胞的死亡. The Journal of Neuroscience. 2009, [80] 唐铁山. 哺乳动物的Y家族DNA聚合酶. Cellular Mol Life Sciences. 2009, [81] 唐铁山. 钙信号紊乱与三型小脑脊髓共济失调病. The Journal of Neuroscience. 2008, [82] 唐铁山. 神经细胞命运决定的一种小分子. Nat Chem Biol. 2008, [83] 唐铁山. Polκ 与泛素的相互作用及其生物学意义. J. Biol. Chem.. 2008, [84] 唐铁山. 多巴胺信号通路与舞蹈病纹状体神经细胞的凋亡. The Journal of Neuroscience. 2007, [85] 唐铁山. Rev1蛋白的泛素结构域在DNA损伤耐受中的作用. Mol Cell Biol. 2006, [86] 唐铁山. 临床相关的谷氨酸信号通路抑制剂对舞蹈病体外模型细胞的保护作用. Neuroscience Letters. 2006, [87] 唐铁山. Rev1与PCNA的相互作用:Rev1的BRCT结构域在功能上的重要意义. Mol Cell. 2006, [88] 唐铁山. 钙信号紊乱与舞蹈病神经细胞的死亡. Proc Natl Acad Sci USA.. 2005, [89] 唐铁山. CaV1.3 L-型钙通道与Shank的相互作用. The Journal of Neuroscience. 2005, [90] Zhang, H, Maximov, A, Fu, Y, Xu, F, Tang, TS, Tkatch, T, Surmeier, DJ, Bezprozvanny, I. Association of Ca(V)1.3 L-type calcium channels with shank. JOURNAL OF NEUROSCIENCE[J]. 2005, 25(5): 1037-1049, https://www.webofscience.com/wos/woscc/full-record/WOS:000226750600001.
[91] Tang, TS, Slow, E, Lupu, V, Stavrovskaya, IG, Sugimori, M, Llinas, R, Kristal, BS, Hayden, MR, Bezprozvanny, I. Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2005, 102(7): 2602-2607, [92] 唐铁山. Reelin对大脑皮层神经元NMDA受体活性的调控作用. The Journal of Neuroscience. 2005, [93] 唐铁山. 三磷酸肌醇受体与AKAP9(油条)和蛋白激酶A的相互作用. J Biol Chem.. 2004, [94] 唐铁山. HAP1促进了突变亨廷顿蛋白对纹状体神经细胞钙信号的上调作用. European Journal of Neuroscience. 2004, [95] 唐铁山. 纹状体神经元多巴胺受体介导的钙信号通路. J Biol Chem.. 2004, [96] 唐铁山. 蛋白激酶A和磷酸酶对三磷酸肌醇受体活性的功能调节. The Journal of Neuroscience. 2003, [97] 唐铁山. 亨廷顿蛋白及其相互作用蛋白对神经细胞钙信号的功能调控. Neuron. 2003, [98] 唐铁山. 神经细胞中三磷酸肌醇受体与4.1N蛋白的相互作用. Mol Cell Neuroscience. 2003, [99] 唐铁山. 精子因子诱导的钙振荡与卵子的母源性机制. Development. 2000, 
发表著作
(1) 《发育生物学》Muller W A原著,《Developmental Biology》Muller W A,高等教育出版社,1998-07,第5作者

科研活动

   
科研项目
( 1 ) 干细胞体内维持分化与功能研究, 负责人, 国家任务, 2011-01--2015-08
( 2 ) 排卵障碍相关疾病发生机制研究, 参与, 国家任务, 2012-01--2016-08
( 3 ) 细胞核内钙信号紊乱在舞蹈病病理发生中的作用机制, 负责人, 国家任务, 2014-01--2017-12
( 4 ) DNA羟甲基化表观修饰调控神经干细胞向神经元分化的分子 机制研究, 负责人, 国家任务, 2016-01--2016-12
( 5 ) 去泛素化酶ataxin-3参与DNA修复通路的分子机制研究, 负责人, 国家任务, 2016-01--2019-12
( 6 ) 多囊卵巢综合征病因学及临床防治研究, 参与, 国家任务, 2017-01--2020-12
( 7 ) CLAC钙通道调控内质网-线粒体互作和线粒体自噬的新机制, 负责人, 国家任务, 2018-01--2021-12
( 8 ) 干细胞的基因组稳定性调控机制及在重大神经疾病猴模型中的临床前评估, 负责人, 国家任务, 2018-07--2022-12
( 9 ) 哺乳动物成体神经干细胞耗竭机制和干预措施的研究, 负责人, 中国科学院计划, 2017-12--2021-12
( 10 ) 衰老机制及调控, 参与, 国家任务, 2020-01--2024-12
( 11 ) TMCO1功能缺陷在脑面胸发育异常疾病中的作用, 负责人, 国家任务, 2021-01--2025-12

指导学生

已指导学生

李晓玲  博士研究生  071009-细胞生物学  

王久强  博士研究生  071009-细胞生物学  

谢文娟  博士研究生  071009-细胞生物学  

王翘楚  博士研究生  071009-细胞生物学  

张阳  硕士研究生  071009-细胞生物学  

王凤丽  博士研究生  071009-细胞生物学  

朱姝  博士研究生  071009-细胞生物学  

曲仲阳  硕士研究生  071009-细胞生物学  

巩娟娟  博士研究生  071009-细胞生物学  

朱雪霏  博士研究生  071009-细胞生物学  

涂英凤  博士研究生  071009-细胞生物学  

汪伦政  硕士研究生  071009-细胞生物学  

安超强  博士研究生  071009-细胞生物学  

王茜  博士研究生  0710J6-再生医学  

卢翰  硕士研究生  071007-遗传学  

现指导学生

杨可言  博士研究生  1001J6-再生医学  

郭英杰  博士研究生  0710J6-再生医学  

塔娜  博士研究生  0710J6-再生医学  

李婷婷  博士研究生  1001J6-再生医学  

程琪  博士研究生  0710J6-再生医学  

孙靖宇  博士研究生  1001J6-再生医学  

高丽洁  博士研究生  1001J6-再生医学  

李欣彤  博士研究生  0710J6-再生医学  

任建平  博士研究生  0710J6-再生医学  

申佳琦  硕士研究生  1001J6-再生医学  

冯海平  博士研究生  1001J6-再生医学  

赵松  博士研究生  1001J6-再生医学  

李郑慧  硕士研究生  0710J6-再生医学  

王思佳  硕士研究生  0710J6-再生医学  

蒋东方  博士研究生  1001J6-再生医学  

张宇馨  硕士研究生  0710J6-再生医学  

吴洪林  博士研究生  1001J6-再生医学