1. RNA在鱼类组织器官发育和再生中的作用与机制

以斑马鱼、青鳉等模式生物为研究对象，探索MicroRNA、LncRNA、RNA结合蛋白等在大脑、性腺、眼、血液等组织器官的发育和再生中的表达动态、相互作用和调控机制，为理解人类疾病或指导遗传育种提供理论依据。

 

2. 感光系统与光周期调控鱼类行为的机制与应用

自然光的昼夜和季节性变化（光周期）指导绝大部分鱼类的生长和繁殖行为。感光系统（眼、松果体等）在监测日照和季节变化中发挥重要作用。在鱼类中，感光系统参与形成昼夜和季节性节律、协调各个器官做出相应反应的分子机制还不完全清楚。以斑马鱼、黄鳝等为模型，通过模拟光周期的变化，结合多组学的研究手段，揭示“光信号-感应细胞-循环系统-效应细胞-个体行为”中缺失的环节，为物种驯化和渔业生产提供理论基础和探索方向。

   

071007-遗传学
090801-水产养殖
071008-发育生物学

鱼类性别分化与遗传育种
鱼类RNA生物学
视觉与光周期

2010-09--2014-12   华中科技大学   博士，理学博士
2009-09--2010-06   华中科技大学   硕士（硕博连读）
2005-09--2009-06   华中科技大学   本科，理学学士

2014-12~2021-05,华中科技大学, 博士后

2021-05~至今,中国科学院水生生物研究所, 副研究员

   

[1] Gao, Pan, Jia, Danna, Li, Pei, Huang, Yuwen, Hualei, Hu, Sun, Kui, Lv, Yuexia, Chen, Xiang, Han, Yunqiao, Zhang, Zuxiao, Ren, Xiang, Wang, Qing, Liu, Fei, Tang, Zhaohui, Liu, Mugen. Accumulation of Lipid Droplets in a Novel Bietti Crystalline Dystrophy Zebrafish Model With Impaired PPARalpha Pathway. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE[J]. 2022, 63(5): 32-, https://iovs.arvojournals.org/article.aspx?articleid=2778864.
[2] Xing Lin, Fei Liu, Kaifeng Meng, Hairong Liu, Yuanli Zhao, Yuanyuan Chen, Wei Hu, Daji Luo, Einar Ring. Comprehensive Transcriptome Analysis Reveals Sex-Specific Alternative Splicing Events in Zebrafish Gonads. LIFE[J]. 2022, 12(9): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501657/.
[3] Liu, Fei, Qin, Yayun, Huang, Yuwen, Gao, Pan, Li, Jingzhen, Yu, Shanshan, Jia, Danna, Chen, Xiang, Lv, Yuexia, Tu, Jiayi, Sun, Kui, Han, Yunqiao, Reilly, James, Shu, Xinhua, Lu, Qunwei, Tang, Zhaohui, Xu, Chengqi, Luo, Daji, Liu, Mugen. Rod genesis driven by mafba in an nrl knockout zebrafish model with altered photoreceptor composition and progressive retinal degeneration. PLOS GENETICS[J]. 2022, 18(3): https://doaj.org/article/5ec87f08a1f5433195e0b9eaee7ac910.
[4] Danna Jia, Pan Gao, Yuexia Lv, Yuwen Huang, James Reilly, Kui Sun, Yunqiao Han, Hualei Hu, Xiang Chen, Zuxiao Zhang, Pei Li, Jiong Luo, Xinhua Shu, Zhaohui Tang, Fei Liu, Mugen Liu, Xiang Ren. Tulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafish. CELL DEATH & DISEASE. 2022, 13(11): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672332/.
[5] Zhao, Yuanli, Chen, Kuangxin, Liu, Fei, Jiang, Mouyan, Chen, Zonggui, Chen, Huijie, Song, Yanlong, Tao, Binbin, Cui, Xuefan, Li, Yongming, Zhu, Zuoyan, Chen, Ji, Hu, Wei, Luo, Daji. Dynamic Gene Expression and Alternative Splicing Events Demonstrate Co-Regulation of Testicular Differentiation and Maturation by the Brain and Gonad in Common Carp. FRONTIERS IN ENDOCRINOLOGY[J]. 2022, 12: http://dx.doi.org/10.3389/fendo.2021.820463.
[6] Chen, Huijie, Zhao, Yuanli, Chen, Kuangxin, Wei, Yulai, Luo, Hongrui, Li, Yongming, Liu, Fei, Zhu, Zuoyan, Hu, Wei, Luo, Daji. Isolation, Identification, and Investigation of Pathogenic Bacteria From Common Carp (Cyprinus carpio) Naturally Infected With Plesiomonas shigelloides. FRONTIERS IN IMMUNOLOGY[J]. 2022, 13: http://dx.doi.org/10.3389/fimmu.2022.872896.
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[9] Qin, Yayun, Gao, Pang, Yu, Shanshan, Li, Jingzhen, Huang, Yuwen, Jia, Danna, Tang, Zhaohui, Li, Pengcheng, Liu, Fei, Liu, Mugen. A large deletion spanning PITX2 and PANCR in a Chinese family with Axenfeld-Rieger syndrome. MOLECULAR VISION[J]. 2020, 26: 670-678, https://www.webofscience.com/wos/woscc/full-record/WOS:000575379500001.
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[13] Qu, Zhen, Yimer, Tinsae Assefa, Xie, Shanglun, Wong, Fulton, Yu, Shanshan, Liu, Xiliang, Han, Shanshan, Ma, Juanjuan, Lu, Zhaojing, Hu, Xuebin, Qin, Yayun, Huang, Yuwen, Lv, Yuexia, Li, Jingzhen, Tang, Zhaohui, Liu, Fei, Liu, Mugen. Knocking out lca5 in zebrafish causes cone-rod dystrophy due to impaired outer segment protein trafficking. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE[J]. 2019, 1865(10): 2694-2705, http://dx.doi.org/10.1016/j.bbadis.2019.07.009.
[14] Hu, Xuebin, Lu, Zhaojing, Yu, Shanshan, Reilly, James, Liu, Fei, Jia, Danna, Qin, Yayun, Han, Shanshan, Liu, Xiliang, Qu, Zhen, Lv, Yuexia, Li, Jingzhen, Huang, Yuwen, Jiang, Tao, Jia, Haibo, Wang, Qing, Liu, Jingyu, Shu, Xinhua, Tang, Zhaohui, Liu, Mugen. CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1. AUTOPHAGY[J]. 2019, 15(3): 453-465, [15] Lu, Zhaojing, Hu, Xuebin, Reilly, James, Jia, Danna, Liu, Fei, Yu, Shanshan, Liu, Xiliang, Xie, Shanglun, Qu, Zhen, Qin, Yayun, Huang, Yuwen, Lv, Yuexia, Li, Jingzhen, Gao, Pan, Wong, Fulton, Shu, Xinhua, Tang, Zhaohui, Liu, Mugen. Deletion of the transmembrane protein Prom1b in zebrafish disrupts outer-segment morphogenesis and causes photoreceptor degeneration. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2019, 294(38): 13953-13963, http://dx.doi.org/10.1074/jbc.RA119.008618.
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[17] Liu, Fei, Qin, Yayun, Yu, Shanshan, Soares, Dinesh C, Yang, Lifang, Weng, Jun, Li, Chang, Gao, Meng, Lu, Zhaojing, Hu, Xuebin, Liu, Xiliang, Jiang, Tao, Liu, Jing Yu, Shu, Xinhua, Tang, Zhaohui, Liu, Mugen. Pathogenic mutations in retinitis pigmentosa 2 predominantly result in loss of RP2 protein stability in humans and zebrafish. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2017, 292(15): 6225-6239, http://dx.doi.org/10.1074/jbc.M116.760314.
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2015.10-2016.12 中国博士后科学基金面上项目，RP2敲除下调RAP1GDS1的机制及其在RP发生中的意义，5万元，主持

2017.1-2019.12 国家自然科学基金青年项目，RP2突变导致其蛋白水平降低并引起视网膜色素变性的机制研究，21万元，主持

2019.1-2022.12 国家自然科学基金面上项目，剪接因子prpf31功能及其突变引起视网膜色素变性和眼发育异常的分子机制，60万元，第二参与人

2019.11-2024.10 中国科学院先导专项A, 鲤高产性状的分子基础-鲤性别控制的RNA基础，100万元，参与人

（ 1 ） 鲤高产性状的分子基础-鲤性别控制的RNA基础, 参与, 部委级, 2019-11--2024-10
（ 2 ） 剪接因子prpf31功能及其突变引起视网膜色素变性和眼发育异常的分子机制, 参与, 国家级, 2019-01--2022-12