基本信息
吴青峰  男  博导  中国科学院遗传与发育生物学研究所
电子邮件: wu_qingfeng@genetics.ac.cn
通信地址: 北京市朝阳区北辰西路1号院2号楼510室
邮政编码: 100101

研究领域

   
领域
神经干细胞, 神经调控代谢

招生信息

   
招生专业
071006-神经生物学
招生方向
神经干细胞

教育背景

2005-09--2012-07   中国科学院神经科学研究所   博士学位
2000-09--2005-07   复旦大学   学士学位
学历

研究生


学位
博士

工作经历

   
工作简历
2016-12~现在, 中国科学院遗传与发育生物学研究所, 研究员
2012-07~2016-08,美国约翰霍普金斯大学, 博士后
研究员
2016-12~现在, 中国科学院遗传与发育生物学研究所, 研究员

专利与奖励

   
专利成果
[1] 吴青峰, 李斯, 穆文辉, 许静凯, 王静静. 一种乳头型颅咽管瘤动物模型的构建方法及应用. CN: CN115125273A, 2022-09-30.

出版信息

   
发表论文
[1] Zhuang, Yanrong, Li, Zhiyuan, Xiong, Shiyue, Sun, Chujie, Li, Boya, Wu, Shuangcheng Alivia, Lyu, Jiali, Shi, Xiang, Yang, Liang, Chen, Yutong, Bao, Zhangbin, Li, Xi, Sun, Chuhanwen, Chen, Yuling, Deng, Haiteng, Li, Tingting, Wu, Qingfeng, Qi, Ling, Huang, Yue, Yang, Xuerui, Lin, Yi. Circadian clocks are modulated by compartmentalized oscillating translation. CELL[J]. 2023, 186(15): 3245-+, http://dx.doi.org/10.1016/j.cell.2023.05.045.
[2] Xiangjia Zhu, Jiaqi Meng, Chaofeng Han, Wu, Qingfeng, Yu Du, Jiao Qi, Ling Wei, Hao Li, Wenwen He, Keke Zhang, Yi Lu. CCL2-mediated inflammatory pathogenesis underlies high myopia-related anxiety. CELL DISCOVERY[J]. 2023, 9: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10497683/.
[3] 王奔, 李斯, 吴青峰, 穆文辉. Ketogenic diet promotes the proliferation of oligodendrocyte precursor cells in ME region by activating fatty acid oxidation. Hereditas (Beijing)[J]. 2023, [4] Yao, Yunqian, Wei, Ling, Chen, Zhenhua, Li, Hao, Qi, Jiao, Wu, Qingfeng, Zhou, Xingtao, Lu, Yi, Zhu, Xiangjia. Single-cell RNA sequencing: Inhibited Notch2 signalling underlying the increased lens fibre cells differentiation in high myopia. CELL PROLIFERATION[J]. 2023, 56(8): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392066/.
[5] Sun, XueLian, Chen, ZhenHua, Guo, Xize, Wang, Jingjing, Ge, Mengmeng, Wong, Samuel Zheng Hao, Wang, Ting, Li, Si, Yao, Mingze, Johnston, Laura A, Wu, QingFeng. Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development. DEVELOPMENTAL CELL[J]. 2023, 58(9): 744-+, http://dx.doi.org/10.1016/j.devcel.2023.03.016.
[6] Yunqian Yao, Zhenhua Chen, Wu, Qingfeng, Yi Lu, Xingtao Zhou, Xiangjia Zhu. Single‐cell RNA sequencing of retina revealed novel transcriptional landscape in high myopia and underlying cell‐type‐specific mechanisms. MEDCOMM[J]. 2023, 4(5): n/a-n/a, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511833/.
[7] Yuqi Miao, Kaiyu Fan, Xiaojiao Peng, Si Li, Jiahui Chen, Robin N. Bai, Yu Wei, Yaxian Deng, Chengsong Zhao, Wu, Qingfeng, Ming Ge, Jian Gong, Di Wu. Postoperative hypothalamic- pituitary dysfunction and long- term hormone replacement in patients with childhood-onset craniopharyngioma. Frontiers in Endocrinology[J]. 2023, [8] Wen, Quan, Weng, Huandi, Liu, Tao, Yu, Lingtai, Zhao, Tainyun, Qin, Jingwen, Li, Si, Wu, Qingfeng, Fadel, Tissir, Qu, Yibo, Zhou, Libing. Inactivating Celsr2 promotes motor axon fasciculation and regeneration in mouse and human. BRAIN[J]. 2022, 145(2): 670-683, http://dx.doi.org/10.1093/brain/awab317.
[9] Yan, Yuze, Tian, Miaomiao, Li, Meng, Zhou, Gang, Chen, Qinan, Xu, Mingrui, Hu, Yi, Luo, Wenhan, Guo, Xiuxian, Zhang, Cheng, Xie, Hong, Wu, QingFeng, Xiong, Wei, Liu, Shiguo, Guan, JiSong. ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder. NEURON[J]. 2022, 110(7): 1156-+, http://dx.doi.org/10.1016/j.neuron.2021.12.035.
[10] Wu, Haoda, Fu, Ruiqing, Zhang, YuHong, Liu, Zhiming, Chen, ZhenHua, Xu, Jingkai, Tian, Yongji, Jin, Wenfei, Wong, Samuel Zheng Hao, Wu, QingFeng. Single-Cell RNA Sequencing Unravels Upregulation of Immune Cell Crosstalk in Relapsed Pediatric Ependymoma. FRONTIERS IN IMMUNOLOGY[J]. 2022, 13: http://dx.doi.org/10.3389/fimmu.2022.903246.
[11] Ge, Mengmeng, Sheikhshahrokh,Amirhossein, Shi, Xiang, Zhang,Yu-hong, Xu, Zhiheng, Wu, Qing-feng. A Spacetime Odyssey of Neural Progenitors to Generate Neuronal Diversity.. Neuroscience Bulletin[J]. 2022, [12] Zhao, Ziqi, Zhang, Dan, Yang, Fuqiang, Xu, Mingrui, Zhao, Shaoli, Pan, Taotao, Liu, Chuanyu, Liu, Yongjie, Wu, Qingfeng, Tu, Qiang, Zhou, Ping, Li, Rong, Kang, Jia, Zhu, Lan, Gao, Fei, Wang, Yaqing, Xu, Zhiheng. Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing. CELL RESEARCH[J]. 2022, 32(5): 425-436, http://lib.cqvip.com/Qikan/Article/Detail?id=7107734159.
[13] Chen, ZhenHua, Li, Si, Xu, Mingrui, Liu, Candace C, Ye, Hongying, Wang, Ben, Wu, QingFeng. Single-cell transcriptomic profiling of the hypothalamic median eminence during aging. JOURNAL OF GENETICS AND GENOMICS[J]. 2022, 49(6): 523-536, http://dx.doi.org/10.1016/j.jgg.2022.01.001.
[14] Yun, Haesung, Dumbell, Rebecca, Hanna, Katie, Bowen, Junior, McLean, Samantha L, Kantamneni, Sriharsha, Pors, Klaus, Wu, QingFeng, Helfer, Gisela. The Chemerin-CMKLR1 Axis is Functionally important for Central Regulation of Energy Homeostasis. FRONTIERS IN PHYSIOLOGY[J]. 2022, 13: http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000811394100001.
[15] Huilin Hong, Zhiguang Zhao, Xiahe Huang, Chao Guo, Hui Zhao, Guo-Dong Wang, Ya-Ping Zhang, Jian-ping Zhao, Jianhui Shi, Qing-Feng Wu, Yong-hui Jiang, Yingchun Wang, 李雷, Zhuo Du, Yong Q. Zhang, Ying Xiong. Comparative proteome and cis-regulatory element analysis reveals specific molecular pathways conserved in dog and human brains. MOLECULAR & CELLULAR PROTEOMICS[J]. 2022, DOI: 10.1016/j.mcpro.2022.100261.
[16] Yan, Yuze, Tian, Miaomiao, Li, Meng, Zhou, Gang, Chen, Qinan, Xu, Mingrui, Hu, Yi, Luo, Wenhan, Guo, Xiuxian, Zhang, Cheng, Xie, Hong, Wu, QingFeng, Xiong, Wei, Liu, Shiguo, Guan, JiSong. ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder. NEURON[J]. 2022, 110(7): 1156-+, http://dx.doi.org/10.1016/j.neuron.2021.12.035.
[17] Shi, Xiang, Zhuang, Yanrong, Chen, Zhenhua, Xu, Mingrui, Kuang, Junqi, Sun, Xue-Lian, Gao, Lisen, Kuang, Xia, Zhang, Huairen, Li, Wei, Wong, Zheng Hao Samuel, Liu, Chuanyu, Liu, Longqi, Jiang, Danhua, Pei, Duanqing,  Lin, Yi,  Wu, Qing-Feng. Hierarchical deployment of Tbx3 dictates the identity of hypothalamic KNDy neurons to control puberty onset. Science Advances[J]. 2022, 8(46): eabq2987-, [18] Chen, Ao, Liao, Sha, Cheng, Mengnan, Ma, Kailong, Wu, Liang, Lai, Yiwei, Qiu, Xiaojie, Yang, Jin, Xu, Jiangshan, Hao, Shijie, Wang, Xin, Lu, Huifang, Chen, Xi, Liu, Xing, Huang, Xin, Li, Zhao, Hong, Yan, Jiang, Yujia, Peng, Jian, Liu, Shuai, Shen, Mengzhe, Liu, Chuanyu, Li, Quanshui, Yuan, Yue, Wei, Xiaoyu, Zheng, Huiwen, Feng, Weimin, Wang, Zhifeng, Liu, Yang, Wang, Zhaohui, Yang, Yunzhi, Xiang, Haitao, Han, Lei, Qin, Baoming, Guo, Pengcheng, Lai, Guangyao, MunozCanoves, Pura, Maxwell, Patrick H, Thiery, Jean Paul, Wu, QingFeng, Zhao, Fuxiang, Chen, Bichao, Li, Mei, Dai, Xi, Wang, Shuai, Kuang, Haoyan, Hui, Junhou, Wang, Liqun, Fei, JiFeng, Wang, Ou, Wei, Xiaofeng, Lu, Haorong, Wang, Bo, Liu, Shiping, Gu, Ying, Ni, Ming, Zhang, Wenwei, Mu, Feng, Yin, Ye, Yang, Huanming, Lisby, Michael, Cornall, Richard J, Mulder, Jan, Uhlen, Mathias, Esteban, Miguel A, Li, Yuxiang, Liu, Longqi, Xu, Xun, Wang, Jian. Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays. CELL[J]. 2022, 185(10): 1777-+, http://dx.doi.org/10.1016/j.cell.2022.04.003.
[19] Zhu, Xiangjia, Du, Yu, Li, Dan, Xu, Jie, Wu, Qingfeng, He, Wenwen, Zhang, Keke, Zhu, Jie, Guo, Linying, Qi, Ming, Liu, Ailin, Qi, Jiao, Wang, Guangyu, Meng, Jiaqi, Yang, Zhenglin, Zhang, Kang, Lu, Yi. Aberrant TGF-beta 1 signaling activation by MAF underlies pathological lens growth in high myopia. NATURE COMMUNICATIONS[J]. 2021, 12(1): http://dx.doi.org/10.1038/s41467-021-22041-2.
[20] Zhang, YuHong, Xu, Mingrui, Shi, Xiang, Sun, XueLian, Mu, Wenhui, Wu, Haoda, Wang, Jingjing, Li, Si, Su, Pengfei, Gong, Ling, He, Miao, Yao, Mingze, Wu, QingFeng. Cascade diversification directs generation of neuronal diversity in the hypothalamus. CELL STEM CELL[J]. 2021, 28(8): 1483-+, http://dx.doi.org/10.1016/j.stem.2021.03.020.
[21] Xiangjia Zhu, Yu Du, Dan Li, Jie Xu, Qingfeng Wu, Wenwen He, Keke Zhang, Jie Zhu, Linying Guo, Ming Qi, Ailin Liu, Jiao Qi, Guangyu Wang, Jiaqi Meng, Zhenglin Yang, Kang Zhang, Yi Lu. Aberrant TGF-β1 signaling activation by MAF underlies pathological lens growth in high myopia. NATURE COMMUNICATIONS[J]. 2021, 12(1): 1-16, http://dx.doi.org/10.1038/s41467-021-22041-2.
[22] Wang, Andi, Wang, Junbao, Tian, Kuan, Huo,Dawei, Ye,Hanzhe, Li,Si, Zhao,Chen, Zhang,Bo, Zheng,Yue, Xu,Lichao, Hua,Xiaojiao, Wang,Kun, Wu,Qing-Feng, Wu,Xudong,  Zeng,Tao, Liu,Ying, Zhou,Yan  . An epigenetic circuit controls neurogenic programs during neocortex development. Development[J]. 2021, 148(22): dev199772-, [23] Wenhui Mu, Si Li, Jingkai Xu, Xize Guo, Haoda Wu, Zhenhua Chen, Lianyong Qiao, Gisela Helfer, Falong Lu, Chong Liu, QingFeng Wu. Hypothalamic Rax(+) tanycytes contribute to tissue repair and tumorigenesis upon oncogene activation in mice. NATURE COMMUNICATIONS[J]. 2021, 12(1): 2288-, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052410/.
[24] Chang, Yafei, Jiang, Yisheng, Li, Cui, Wang, Qin, Zhang, Feng, Qin, ChengFeng, Wu, QingFeng, Li, Jing, Xu, Zhiheng. Different Gene Networks Are Disturbed by Zika Virus Infection in A Mouse Microcephaly Model. GENOMICS PROTEOMICS & BIOINFORMATICS[J]. 2020, 18(6): 737-748, http://dx.doi.org/10.1016/j.gpb.2019.06.0041672-0229.
[25] Wang, Jingjing, Li, Tong, Wang, JingLi, Xu, Zhiheng, Meng, Wenxiang, Wu, QingFeng. Talpid3-Mediated Centrosome Integrity Restrains Neural Progenitor Delamination to Sustain Neurogenesis by Stabilizing Adherens Junctions. CELL REPORTS[J]. 2020, 33(11): https://doaj.org/article/b95037e5ffcf4b4b8e9369abdcd4d618.
[26] Berg, Daniel A, Su, Yijing, JimenezCyrus, Dennisse, Patel, Aneek, Huang, Nancy, Morizet, David, Lee, Stephanie, Shah, Reeti, Ringeling, Francisca Rojas, Jain, Rajan, Epstein, Jonathan A, Wu, QingFeng, Canzar, Stefan, Ming, GuoLi, Song, Hongjun, Bond, Allison M. A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis. CELL[J]. 2019, 177(3): 654-+, http://dx.doi.org/10.1016/j.cell.2019.02.010.
[27] Tang, Changyong, Wang, Min, Wang, Peijian, Wang, Lei, Wu, Qingfeng, Guo, Weixiang. Neural Stem Cells Behave as a Functional Niche for the Maturation of Newborn Neurons through the Secretion of PTN. NEURON[J]. 2019, 101(1): 32-+, http://dx.doi.org/10.1016/j.neuron.2018.10.051.
[28] Wong, Samuel Z H, Scott, Earl Parker, Mu, Wenhui, Guo, Xize, Borgenheimer, Ella, Freeman, Madeline, Ming, Guoli, Wu, QingFeng, Song, Hongjun, Nakagawa, Yasushi. In vivo clonal analysis reveals spatiotemporal regulation of thalamic nucleogenesis. PLOS BIOLOGY[J]. 2018, 16(4): https://doaj.org/article/1b423e908818445bae57968860a212c6.
[29] Mingrui Xu, Jingjing Wang, Xize Guo, Tingting Li, Xia Kuang, QingFeng Wu. Illumination of neural development by invivo clonal analysis. CELLREGENERATION[J]. 2018, 7(2): 33-39, http://dx.doi.org/10.1016/j.cr.2018.09.001.
[30] Wei, Dan, Gao, Nannan, Li, Lei, Zhu, JingXiang, Diao, Lei, Huang, Jiansong, Han, QingJian, Wang, Shaogang, Xue, Huaqing, Wang, Qiong, Wu, QingFeng, Zhang, Xu, Bao, Lan. alpha-Tubulin Acetylation Restricts Axon Overbranching by Dampening Microtubule Plus-End Dynamics in Neurons. CEREBRAL CORTEX[J]. 2018, 28(9): 3332-3346, http://202.127.25.143/handle/331003/3377.
[31] Helfer, Gisela, Wu, QingFeng. Chemerin: a multifaceted adipokine involved in metabolic disorders. JOURNAL OF ENDOCRINOLOGYnull. 2018, 238(2): R79-R94, https://www.webofscience.com/wos/woscc/full-record/WOS:000438707700002.
[32] Yang, Liu, Dong, Fei, Yang, Qing, Yang, PaiFeng, Wu, Ruiqi, Wu, QingFeng, Wu, Dan, Li, ChangLin, Zhong, YanQing, Lu, YingJin, Cheng, Xiaoyang, Xu, FuQiang, Chen, Limin, Bao, Lan, Zhang, Xu. FGF13 Selectively Regulates Heat Nociception by Interacting with Na(v)1.7. NEURON[J]. 2017, 93(4): 806-+, http://dx.doi.org/10.1016/j.neuron.2017.01.009.
[33] Yoon, KiJun, Song, Guang, Qian, Xuyu, Pan, Jianbo, Xu, Dan, Rho, HeeSool, Kim, NamShik, Habela, Christa, Zheng, Lily, Jacob, Fadi, Zhang, Feiran, Lee, Emily M, Huang, WeiKai, Ringeling, Francisca Rojas, Vissers, Caroline, Li, Cui, Yuan, Ling, Kang, Koeun, Kim, Sunghan, Yeo, Junghoon, Cheng, Yichen, Liu, Sheng, Wen, Zhexing, Qin, ChengFeng, Wu, Qingfeng, Christian, Kimberly M, Tang, Hengli, Jin, Peng, Xu, Zhiheng, Qian, Jiang, Zhu, Heng, Song, Hongjun, Ming, Guoli. Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins. CELL STEM CELL[J]. 2017, 21(3): 349-+, http://dx.doi.org/10.1016/j.stem.2017.07.014.
[34] Oh, Yohan, Zhang, Feiran, Wang, Yaqing, Lee, Emily M, Choi, In Young, Lim, Hotae, Mirakhori, Fahimeh, Li, Ronghua, Huang, Luoxiu, Xu, Tianlei, Wu, Hao, Li, Cui, Qin, ChengFeng, Wen, Zhexing, Wu, QingFeng, Tang, Hengli, Xu, Zhiheng, Jin, Peng, Song, Hongjun, Ming, Guoli, Lee, Gabsang. Zika virus directly infects peripheral neurons and induces cell death. NATURE NEUROSCIENCE[J]. 2017, 20(9): 1209-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000408587700006.
[35] Liu, Hui, Wu, QingFeng, Li, JiaYin, Liu, XingJun, Li, KaiCheng, Zhong, YanQing, Wu, Dan, Wang, Qiong, Lu, YinJing, Bao, Lan, Zhang, Xu. Fibroblast growth factor 7 is a nociceptive modulator secreted via large dense-core vesicles. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2015, 7(5): 466-475, http://ir.sibs.ac.cn/handle/331001/3930.
[36] Wu, QingFeng, Yang, Liu, Li, Shuai, Wang, Qiong, Yuan, XiaoBin, Gao, Xiang, Bao, Lan, Zhang, Xu. Fibroblast Growth Factor 13 Is a Microtubule-Stabilizing Protein Regulating Neuronal Polarization and Migration. CELL[J]. 2012, 149(7): 1549-1564, http://dx.doi.org/10.1016/j.cell.2012.04.046.
[37] Liu, XingJun, Zhang, FangXiong, Liu, Hui, Li, KaiCheng, Lu, YingJin, Wu, QingFeng, Li, JiaYin, Wang, Bin, Wang, Qiong, Lin, LiBo, Zhong, YanQing, Xiao, HuaSheng, Bao, Lan, Zhang, Xu. Activin C expressed in nociceptive afferent neurons is required for suppressing inflammatory pain. BRAIN[J]. 2012, 135: 391-403, http://www.irgrid.ac.cn/handle/1471x/502153.
[38] Zhang Xu, Bao Lan, Yang Liu, Wu QingFeng, Li Shuai. Roles of intracellular fibroblast growth factors in neural development and functions. SCIENCE CHINA-LIFE SCIENCES[J]. 2012, 55(12): 1038-1044, http://www.irgrid.ac.cn/handle/1471x/647542.
[39] Helfer Gisela, Wu Qing-Feng. Chemerin: a multifaceted adipokine involved in metabolic disorders. THE JOURNAL OF ENDOCRINOLOGY. 238(2): R79-R94, [40] XueLian Sun, ZhenHua Chen, Xize Guo, Jingjing Wang, Mengmeng Ge, Samuel Zheng Hao Wong, Ting Wang, Si Li, Mingze Yao, Laura A Johnston, QingFeng Wu. Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development. DEVELOPMENTAL CELL. http://dx.doi.org/10.1016/j.devcel.2023.03.016.

科研活动

   
科研项目
( 1 ) 克隆分析法在体研究核团结构中神经干细胞的属性和自我更新的分子机制, 主持, 国家级, 2018-01--2021-12
( 2 ) 脊髓损伤后再生微环境构建, 主持, 国家级, 2019-01--2023-12
( 3 ) 自闭症和抑郁症社交与情感障碍神经环路机制研究, 主持, 省级, 2018-09--2021-08

指导学生

现指导学生

王景丽  博士研究生  071008-发育生物学  

郭曦泽  博士研究生  071009-细胞生物学  

李彤  硕士研究生  071006-神经生物学  

李斯  博士研究生  071006-神经生物学  

许鸣锐  博士研究生  071006-神经生物学  

童曈  硕士研究生  071006-神经生物学  

张宇虹  硕士研究生  071007-遗传学